Abstract | AIM OF STUDY: MATERIALS AND METHODS: The rats were treated with their respective treatments for 2 weeks prior to the MCAO, continually treated for another 7 days after MCAO. During the post-surgery treatment period, neurological deficit score was measured. At the end of treatment, animals were sacrificed and samples were collected for analysis of infarct volume, apoptosis and antioxidant analysis. RESULTS: Under the treatment of pHL, the infarct volume was reduced significantly from 20.75+/-0.03% to 15.19+/-0.02% (p<0.05). The neurological impairment was alleviated to 1.82 as compared to vehicle (2.43). Plasma antioxidant concentration was increased from 0.31+/-0.03 mM to 0.42+/-0.05 mM (p<0.05). DNA oxidative damage was reduced to 1.19+/-0.03 in stroke pHL treated group (p<0.05 as compared to vehicle group, 1.78+/-0.03). pHL could reduce the level of apoptosis and also the pro-apoptotic proteins, but increase the level of anti-apoptotic proteins. CONCLUSION:
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Authors | Kok Poh Loh, Shan Hong Huang, Benny Kwong Huat Tan, Yi Zhun Zhu |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 125
Issue 2
Pg. 337-43
(Sep 07 2009)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 19497358
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Drugs, Chinese Herbal
- Neuroprotective Agents
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Topics |
- Animals
- Antioxidants
(metabolism, pharmacology)
- Apoptosis
(drug effects)
- Brain
(drug effects)
- DNA Damage
(drug effects)
- Disease Models, Animal
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Infarction, Middle Cerebral Artery
(drug therapy)
- Leonurus
(chemistry)
- Motor Activity
(drug effects)
- Neuroprotective Agents
(pharmacology, therapeutic use)
- Phytotherapy
- Rats
- Rats, Wistar
- Stroke
(drug therapy)
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