[Features of oxidation of reserve lipids in liver mitochondria during starvation: the role of non-heme iron and free radical fatty acid oxidation].

Abstract

Structure-functional transformation fo respiratory chain, developed in response to 72 hrs starvation involved the following alterations: 1. in mitochondria of starved rats distinct increase ws observed in sensitivity of palmitocarnitine oxidation, but not of succinate, to benzhydroxamic acid--chelator of non-heme iron; 2. as compared with controls accumulation of malonic dialdehyde was completely inhibited in liver mitochondria of the starved rats in presence of benzhydroxamic acid; 3. considerable alteration in sensitivity of respiration and ATP synthesis to the effect of some inhibitors was found in liver mitochondria of starved rats. Results of the experiment are discussed on the basis of the assumption that existence of additional pathways of ATP synthesis, essential for adaptation-restoration processes, is biologically important under conditions of stress.

• Authors: L E Panin, D I Kuz'menko
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1991 May-Jun Vol. 37 Issue 3 Pg. 5-9 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Osobennosti okisleniia rezervnykh lipidov v mitokhondriiakh pecheni pri golodanii: rol' negemovogo zheleza i svobodnoradikal'nogo okisleniia zhirnykh kislot.
• PMID: 1949686 (Publication Type: English Abstract, Journal Article)

Chemical References

• Fatty Acids
• Free Radicals
• Hydroxamic Acids
• Palmitoylcarnitine
• Malondialdehyde
• Adenosine Triphosphate
• Iron
• benzohydroxamic acid
• Potassium Cyanide

Topics

• Adenosine Triphosphate (biosynthesis)
• Animals
• Fatty Acids (metabolism)
• Free Radicals
• Hydroxamic Acids (pharmacology)
• Iron (metabolism)
• Male
• Malondialdehyde (metabolism)
• Mitochondria, Liver (drug effects, metabolism)
• Oxidation-Reduction
• Palmitoylcarnitine (metabolism)
• Potassium Cyanide (pharmacology)
• Rats
• Rats, Inbred Strains
• Starvation (metabolism)