HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Murine model of hypereosinophilic syndromes/chronic eosinophilic leukemia.

Abstract
Hypereosinophilic syndrome (HES) includes heterogeneous hematological disorders that are characterized by distinctive blood and tissue eosinophilia. In addition to classical HES criteria, the World Health Organization proposed a set of criteria that distinguish chronic eosinophilic leukemia (CEL) from HES. As such, the fusion gene FIP1L1/PDGFRA was found as a cause of CEL in a significant proportion of patients initially diagnosed as having HES. Several investigations have tried to dissect the mechanism of leukemogenesis; eosinophilia and signaling induced by FIP1L1/PDGFRalpha in cell lines, bone marrow mast cells, primary human eosinophils and in murine myeloproliferative disorder models. In this review, we introduce the current knowledge on the relationship between FIP1L1/PDGFRalpha and cell signaling, eosinophil proliferation, survival and activation and mastocytosis specially focusing on the evidence learned from murine models.
AuthorsYoshiyuki Yamada, Jose A Cancelas, Marc E Rothenberg
JournalInternational archives of allergy and immunology (Int Arch Allergy Immunol) Vol. 149 Suppl 1 Pg. 102-7 ( 2009) ISSN: 1423-0097 [Electronic] Switzerland
PMID19494514 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright 2009 S. Karger AG, Basel.
Chemical References
  • Benzamides
  • Oncogene Proteins, Fusion
  • Piperazines
  • Protein Kinase Inhibitors
  • Pyrimidines
  • mRNA Cleavage and Polyadenylation Factors
  • Imatinib Mesylate
  • FIP1L1-PDGFRA fusion protein, human
  • Receptor, Platelet-Derived Growth Factor alpha
Topics
  • Animals
  • Benzamides
  • Chronic Disease
  • Disease Models, Animal
  • Eosinophils (immunology)
  • Humans
  • Hypereosinophilic Syndrome (complications, diagnosis, drug therapy, metabolism)
  • Imatinib Mesylate
  • Mastocytosis (etiology, metabolism)
  • Mice
  • Oncogene Proteins, Fusion (chemistry, genetics)
  • Piperazines (therapeutic use)
  • Protein Kinase Inhibitors (therapeutic use)
  • Pyrimidines (therapeutic use)
  • Receptor, Platelet-Derived Growth Factor alpha (chemistry, genetics)
  • Signal Transduction
  • mRNA Cleavage and Polyadenylation Factors (chemistry, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: