Abstract | AIMS: METHODS: Balb/c mice received icy injection of D609/PBN plus facial carrageenan injection, and the number of face wash strokes to von Frey hair mechanical stimulation of the maxillary skin was quantified. PtdCho-PLC and ASMase activities were also assayed in the brainstem, thalamus, and somatosensory cortex. RESULTS: Mice that received the icy injection of 10 nmol D609 plus facial carrageenan injection showed significantly fewer face wash strokes evoked by von Frey hair stimulation (indicating reduced mechanical allodynia) at 1 and 3 days post-injection, compared to mice that received icy injection of isotonic saline plus facial carrageenan injection. Mice that received icy injection of 1.13 micromol PBN plus facial carrageenan injection likewise showed significantly fewer face wash strokes after facial carrageenan injection, compared to isotonic saline-injected plus carrageenan-injected controls. D609 injection also resulted in significantly reduced ASMase activity in the brainstem, thalamus, and somatosensory cortex 3 days after injection, compared to controls. CONCLUSION:
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Authors | Ning Tang, Wei-Yi Ong, Jin-Fei Yeo, Akhlaq A Farooqui |
Journal | Journal of orofacial pain
(J Orofac Pain)
Vol. 23
Issue 2
Pg. 167-73
( 2009)
ISSN: 1064-6655 [Print] United States |
PMID | 19492541
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Bridged-Ring Compounds
- Cyclic N-Oxides
- Free Radical Scavengers
- Norbornanes
- Sphingolipids
- Thiocarbamates
- Thiones
- phenyl-N-tert-butylnitrone
- tricyclodecane-9-yl-xanthogenate
- Carrageenan
- Type C Phospholipases
- Sphingomyelin Phosphodiesterase
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Topics |
- Animals
- Antioxidants
(administration & dosage, therapeutic use)
- Brain
(drug effects, enzymology)
- Brain Stem
(drug effects, enzymology)
- Bridged-Ring Compounds
(administration & dosage, therapeutic use)
- Carrageenan
(adverse effects)
- Cerebral Ventricles
(drug effects, enzymology)
- Cyclic N-Oxides
(administration & dosage, therapeutic use)
- Disease Models, Animal
- Facial Pain
(chemically induced, drug therapy)
- Free Radical Scavengers
(administration & dosage, therapeutic use)
- Injections, Intraventricular
- Male
- Maxillary Nerve
(drug effects)
- Mice
- Mice, Inbred BALB C
- Norbornanes
- Somatosensory Cortex
(drug effects, enzymology)
- Sphingolipids
(metabolism)
- Sphingomyelin Phosphodiesterase
(antagonists & inhibitors)
- Stimulation, Chemical
- Thalamus
(drug effects, enzymology)
- Thiocarbamates
- Thiones
(administration & dosage, therapeutic use)
- Trigeminal Ganglion
(drug effects)
- Type C Phospholipases
(antagonists & inhibitors)
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