Prescription of fondaparinux in hospitalised patients.

Fondaparinux is an antithrombotic agent with unique properties that may offer benefit to patients beyond the current approved indications. To explore the off-label use versus approved use of fondaparinux, we initiated a single-center registry of fondaparinux use. During the 25-month study period, 219 patients were prescribed fondaparinux: 157 (71.7%) for prophylaxis and 62 (28.3%) patients for the treatment of thrombosis. When fondaparinux was used for prophylaxis in our registry, 94% of patients had documentation of heparin-induced thrombocytopenia (HIT). Fondaparinux warrants further evaluation in patients with HIT or suspected HIT. In the meantime, its off-label use may exceed its use for FDA-approved indications.
AuthorsSteven Baroletti, Matthew Labreche, Matthew Niles, John Fanikos, Samuel Z Goldhaber
JournalThrombosis and haemostasis (Thromb Haemost) Vol. 101 Issue 6 Pg. 1091-4 (Jun 2009) ISSN: 0340-6245 [Print] Germany
PMID19492152 (Publication Type: Journal Article)
Chemical References
  • Fibrinolytic Agents
  • Polysaccharides
  • Heparin
  • fondaparinux
  • Adult
  • Aged
  • Drug Prescriptions
  • Female
  • Fibrinolytic Agents (administration & dosage, adverse effects)
  • Heparin (administration & dosage, adverse effects)
  • Hospitals
  • Humans
  • Male
  • Middle Aged
  • Orthopedic Procedures
  • Perioperative Care
  • Polysaccharides (administration & dosage, adverse effects)
  • Pulmonary Embolism (drug therapy)
  • Registries
  • Risk Factors
  • Thrombocytopenia (chemically induced, drug therapy)
  • Treatment Outcome
  • Venous Thromboembolism (drug therapy, surgery)
  • Venous Thrombosis (drug therapy)

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