Detection of retinal metabolic stress resulting from central serous retinopathy.

Abstract

PURPOSE:

To test whether eyes with central serous retinopathy have elevated retinal flavoprotein fluorescence (FPF) using a novel clinical imaging method.

METHODS:

Three male patients with unilateral central serous retinopathy were examined for FPF at 535 nm induced by 1-msec flashes of 467 nm light. FPF was captured with an electron multiplying charged-coupled device camera with a 512 x 512 pixel chip. Average intensity of retinal FPF for each affected eye was compared with the contralateral, unaffected eye and with six age-matched control eyes by analyzing histograms of pixel intensities plotted for each eye.

RESULTS:

For each patient, the central serous retinopathy-affected eye had a significantly greater retinal FPF when compared with the retinal FPF of the unaffected eye. Eyes affected with central serous retinopathy had retinal FPF values that averaged 98% greater than the retinal FPF of age-matched control eyes.

CONCLUSION:

Flavoprotein fluorescence analysis may be useful for rapidly and noninvasively identifying metabolic tissue stress of central serous retinopathy.

• Authors: Matthew G Field, Victor M Elner, Seung Park, Richard Hackel, John R Heckenlively, Susan G Elner, Howard R Petty
• Journal: Retina (Philadelphia, Pa.) (Retina) Vol. 29 Issue 8 Pg. 1162-6 (Sep 2009) ISSN: 1539-2864 [Electronic] United States
• PMID: 19491721 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• Flavoproteins

Topics

• Adult
• Biomarkers
• Central Serous Chorioretinopathy (metabolism, pathology, physiopathology)
• Flavoproteins (analysis, metabolism)
• Fluorescein Angiography
• Fluorescence
• Humans
• Male
• Oxidative Stress
• Reproducibility of Results
• Retina (metabolism, pathology, physiopathology)