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The Ala allele at Val762Ala polymorphism in poly(ADP-ribose) polymerase-1 (PARP-1) gene is associated with a decreased risk of asthma in a Turkish population.

AbstractBACKGROUND AND OBJECTIVE:
It has been suggested that inhibition of poly (ADP-ribose) polymerase-1 (PARP-1), either pharmacologically or by a gene knockout provides significant protection against systemic or tissue inflammation in animal models. The aim of this study was to analyze the association of the PARP-1 Val762Ala polymorphism, which has beenreported to be associated with decreased enzymatic activity, in Turkish patients with adult asthma.
METHODS:
A total of 112 subjects with stable asthma and 180 normal controls from the same geographic region were studied and polymerase chain reaction-based restriction analysis was used to identify Val762Ala polymorphism of the PARP-1.
RESULTS:
In univariate analysis, PARP-1 762 AA genotype conferred a 3.4 fold reduction in risk (OR = 0.297, 95% CI = 0.105-0.813; P = 0.014), while heterozygous VA genotype conferred an even greater level of protection (OR = 0.06; 95%CI, 0.026-0.14; P < 10(-6)). In addition, wild type PARP-1 762 V allele had 5 times the risk of developing asthma than those without the allele (OR 0.199, CI 0.118-0.334, P = 10(-6)).
CONCLUSIONS:
These findings suggest that PARP-1 V762A variants may be one of the factors participating in protection or susceptibility to asthma in our population.
AuthorsGulçin Tezcan, Cigdem Bayram Gurel, Bulent Tutluoglu, Ilhan Onaran, Gonul Kanigur-Sultuybek
JournalThe Journal of asthma : official journal of the Association for the Care of Asthma (J Asthma) Vol. 46 Issue 4 Pg. 371-4 (May 2009) ISSN: 1532-4303 [Electronic] United States
PMID19484672 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Poly Adenosine Diphosphate Ribose
  • Poly(ADP-ribose) Polymerases
Topics
  • Age Distribution
  • Alleles
  • Analysis of Variance
  • Asthma (diagnosis, epidemiology, genetics)
  • Case-Control Studies
  • Confidence Intervals
  • Female
  • Gene Expression Regulation
  • Genetic Predisposition to Disease (epidemiology)
  • Humans
  • Incidence
  • Male
  • Odds Ratio
  • Poly Adenosine Diphosphate Ribose (genetics, metabolism)
  • Poly(ADP-ribose) Polymerases (genetics, metabolism)
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Probability
  • Prognosis
  • Reference Values
  • Risk Assessment
  • Severity of Illness Index
  • Sex Distribution
  • Turkey (epidemiology)

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