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Treatment-resistant meningitis leading to the diagnosis of Currarino syndrome: a case report.

Abstract
A 20-day-old female infant developed fever. Sepsis evaluation revealed cerebrospinal fluid (CSF) pleocytosis and a modestly decreased CSF glucose. After 48 hours of broad-spectrum antibiotics, the infant remained febrile. Repeat CSF analysis showed increased pleocytosis and a very low glucose value. Subsequently, a rectothecal fistula and sacral abnormalities were found, leading to the diagnosis of Currarino syndrome. Parameningeal foci should be considered in treatment-resistant meningitis.
AuthorsAutumn S Kiefer, Priyanka Gupta, Salman Kirmani, Kara Schwartz, Nancy Henry, Philip R Fischer
JournalThe Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 28 Issue 6 Pg. 547-9 (Jun 2009) ISSN: 0891-3668 [Print] United States
PMID19483525 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Antiviral Agents
  • Homeodomain Proteins
  • MNX1 protein, human
  • Transcription Factors
Topics
  • Abnormalities, Multiple (diagnosis)
  • Anal Canal (abnormalities)
  • Anti-Bacterial Agents (therapeutic use)
  • Antiviral Agents (therapeutic use)
  • Constriction, Pathologic
  • Female
  • Homeodomain Proteins (genetics)
  • Humans
  • Infant, Newborn
  • Meningitis (cerebrospinal fluid, diagnosis, drug therapy)
  • Meningocele
  • Rectal Fistula
  • Sacrum (abnormalities)
  • Syndrome
  • Transcription Factors (genetics)

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