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Macelignan attenuates activations of mitogen-activated protein kinases and nuclear factor kappa B induced by lipopolysaccharide in microglial cells.

Abstract
A previous study showed that macelignan extracted from Myristica fragrans has anti-inflammatory properties using hippocampal neuronal and primary microglial cells. Subsequently, a study using animals with chronic lipopolysaccharide (LPS) infusion into the brain showed that oral treatments of macelignan reduced the hippocampal microglial activation and hippocampal-dependent spatial memory impairments induced by LPS. However, the molecular mechanisms responsible for the anti-inflammatory activity of macelignan have not been elucidated in the microglia. Therefore, the present study was conducted to determine if mitogen-activated protein kinase (MAPK) signaling and nuclear factor-kappa B (NF-kappaB) activities are related to the anti-inflammatory effects of macelignan on LPS-stimulated BV-2 microglial cells. The results show that macelignan suppresses both the phosphorylations of MAPKs and the degradation of inhibitory-kappa B (IkappaBalpha) and increases of nuclear NF-kappaB in LPS-stimulated BV-2 microglial cells. These results suggest that macelignan has an anti-inflammatory effect on the affected brain through regulation of the inflammation through the MAPK signal pathway.
AuthorsJinhua Ma, Yoo Kyeong Hwang, Woo-Hyun Cho, Seol-Heui Han, Jae Kwan Hwang, Jung-Soo Han
JournalBiological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 32 Issue 6 Pg. 1085-90 (Jun 2009) ISSN: 0918-6158 [Print] Japan
PMID19483320 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Lignans
  • Lipopolysaccharides
  • NF-kappa B
  • macelignan
  • Mitogen-Activated Protein Kinases
Topics
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (isolation & purification, pharmacology)
  • Blotting, Western
  • Cell Line
  • Cell Nucleus (drug effects, enzymology, metabolism)
  • Cell Survival (drug effects)
  • Cytoplasm (drug effects, enzymology, metabolism)
  • Lignans (isolation & purification, pharmacology)
  • Lipopolysaccharides
  • Mice
  • Microglia (drug effects, enzymology, metabolism)
  • Mitogen-Activated Protein Kinases (metabolism)
  • Myristica (chemistry)
  • NF-kappa B (metabolism)
  • Phosphorylation
  • Signal Transduction (drug effects)

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