Urinary bone resorption markers (deoxypyridinoline and C-terminal telopeptide of type I collagen) in healthy persons, postmenopausal osteoporosis and patients with type I diabetes.

Abstract

PURPOSE:

Deoxypyridinoline (DPD) is a derivative of hydroxypyridinium, which is released during bone resorption into the blood stream and is eliminated unmodified with urine. A further collagen-derived marker of bone resorption is the C-terminal telopeptide of type I collagen (beta-CTX-I, here abbreviated as CTX), which is released in bone resorption and almost entirely excreted by the kidneys. The aim of our study was to investigate different well-described patient groups as well as normal probands in view of differences and expected correlations of these two parameters: patients with insulin-dependent diabetes mellitus, postmenopausal women with osteoporosis and healthy control persons.

MATERIALS AND METHODS:

We used a solid-phase chemiluminescence enzyme immunoassay (Pyrilinks D-IMMULITE) for urinary DPD measurement and for the assessment of urinary CTX we used a quantitative ELISA (Osteometer Biotec A-S, CrossLaps ELISA).

RESULTS:

We found a highly significant correlation between both parameters in the group of healthy persons (r = 0.75, p < 0.05, n = 28) as well as in the group of patients with diabetes mellitus type I (r = 0.79, p < 0.05, n = 65). Also, a significant correlation was observed between DPD and CTX (r = 0.583, p < 0.05, n = 88) in the group of female osteoporotic patients.

CONCLUSIONS:

Despite good correlations between DPD and CTX in all of the investigated groups, these urinary markers were of limited diagnostic significance in the group of postmenopausal osteoporosis due to a wide spread (few patients showed concentrations above the range of healthy persons) in this newly diagnosed drug-naïve patient collective.

• Authors: W J Fassbender, M Gödde, V M Brandenburg, K H Usadel, U C Stumpf
• Journal: Advances in medical sciences (Adv Med Sci) Vol. 54 Issue 1 Pg. 1-6 ( 2009) ISSN: 1898-4002 [Electronic] Netherlands
• PMID: 19482729 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Amino Acids
• Biomarkers
• Collagen Type I
• Peptides
• collagen type I trimeric cross-linked peptide
• deoxypyridinoline

Topics

• Adult
• Aged
• Aged, 80 and over
• Amino Acids (immunology, urine)
• Biomarkers (urine)
• Bone Density
• Bone Resorption (diagnosis, physiopathology, urine)
• Collagen Type I (immunology, urine)
• Confidence Intervals
• Diabetes Mellitus, Type 1 (physiopathology, urine)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Luminescent Measurements
• Male
• Middle Aged
• Osteoporosis, Postmenopausal (physiopathology, urine)
• Peptides (immunology, urine)
• Regression Analysis
• Young Adult