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Effect of red wine on urinary protein, 8-hydroxydeoxyguanosine, and liver-type fatty acid-binding protein excretion in patients with diabetic nephropathy.

Abstract
The aim of the present study was to determine whether red or white wine affects urinary protein, 8-hydroxydeoxyguanosine (8-OHdG), and liver-type fatty acid-binding protein (L-FABP) excretion in type 2 diabetic nephropathy patients. Twenty-four type 2 diabetes mellitus patients with nephropathy were randomly allocated to drink a 118-mL (4-oz) glass of red wine (n = 12, group A) or white wine (n = 12, group B) daily for 6 months. Twelve type 2 diabetes mellitus patients with nephropathy who did not drink any wines served as control subjects (group C). Serum creatinine, 24-hour creatinine clearance, hemoglobin A(1c), urinary protein, urinary 8-OHdG, and urinary L-FABP were measured before and 3 and 6 months after the start of the study. In groups A, B, and C, serum creatinine, 24-hour creatinine clearance, and hemoglobin A(1c) changed little during the experimental period. However, urinary protein, 8-OHdG, and L-FABP excretions were significantly decreased at 3 (P < .05) and 6 months (P < .01) compared with the baseline values in group A. In contrast, these markers changed little during the experimental period in groups B and C. Thus, these urinary markers were significantly lower in group A than in groups B and C at 3 and 6 months. These results suggest that red wine is renoprotective whereas white wine has no such effect in type 2 diabetes mellitus patients with nephropathy. The renoprotective effect of red wine may be due in part to its ability to reduce oxidative stress.
AuthorsTsukasa Nakamura, Nobuharu Fujiwara, Takeshi Sugaya, Yoshihiko Ueda, Hikaru Koide
JournalMetabolism: clinical and experimental (Metabolism) Vol. 58 Issue 8 Pg. 1185-90 (Aug 2009) ISSN: 1532-8600 [Electronic] United States
PMID19481229 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Antihypertensive Agents
  • Biomarkers
  • FABP1 protein, human
  • Fatty Acid-Binding Proteins
  • Hypoglycemic Agents
  • 8-Hydroxy-2'-Deoxyguanosine
  • Deoxyguanosine
Topics
  • 8-Hydroxy-2'-Deoxyguanosine
  • Adult
  • Aged
  • Antihypertensive Agents (therapeutic use)
  • Biomarkers (urine)
  • Deoxyguanosine (analogs & derivatives, urine)
  • Diabetes Mellitus, Type 2 (complications)
  • Diabetic Nephropathies (drug therapy, urine)
  • Fatty Acid-Binding Proteins (urine)
  • Female
  • Humans
  • Hypoglycemic Agents (therapeutic use)
  • Male
  • Middle Aged
  • Oxidative Stress
  • Proteinuria (prevention & control)
  • Time Factors
  • Wine

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