Abstract |
The aim of the present study was to determine whether red or white wine affects urinary protein, 8-hydroxydeoxyguanosine (8-OHdG), and liver-type fatty acid-binding protein (L-FABP) excretion in type 2 diabetic nephropathy patients. Twenty-four type 2 diabetes mellitus patients with nephropathy were randomly allocated to drink a 118-mL (4-oz) glass of red wine (n = 12, group A) or white wine (n = 12, group B) daily for 6 months. Twelve type 2 diabetes mellitus patients with nephropathy who did not drink any wines served as control subjects (group C). Serum creatinine, 24-hour creatinine clearance, hemoglobin A(1c), urinary protein, urinary 8-OHdG, and urinary L-FABP were measured before and 3 and 6 months after the start of the study. In groups A, B, and C, serum creatinine, 24-hour creatinine clearance, and hemoglobin A(1c) changed little during the experimental period. However, urinary protein, 8-OHdG, and L-FABP excretions were significantly decreased at 3 (P < .05) and 6 months (P < .01) compared with the baseline values in group A. In contrast, these markers changed little during the experimental period in groups B and C. Thus, these urinary markers were significantly lower in group A than in groups B and C at 3 and 6 months. These results suggest that red wine is renoprotective whereas white wine has no such effect in type 2 diabetes mellitus patients with nephropathy. The renoprotective effect of red wine may be due in part to its ability to reduce oxidative stress.
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Authors | Tsukasa Nakamura, Nobuharu Fujiwara, Takeshi Sugaya, Yoshihiko Ueda, Hikaru Koide |
Journal | Metabolism: clinical and experimental
(Metabolism)
Vol. 58
Issue 8
Pg. 1185-90
(Aug 2009)
ISSN: 1532-8600 [Electronic] United States |
PMID | 19481229
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Antihypertensive Agents
- Biomarkers
- FABP1 protein, human
- Fatty Acid-Binding Proteins
- Hypoglycemic Agents
- 8-Hydroxy-2'-Deoxyguanosine
- Deoxyguanosine
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Adult
- Aged
- Antihypertensive Agents
(therapeutic use)
- Biomarkers
(urine)
- Deoxyguanosine
(analogs & derivatives, urine)
- Diabetes Mellitus, Type 2
(complications)
- Diabetic Nephropathies
(drug therapy, urine)
- Fatty Acid-Binding Proteins
(urine)
- Female
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Male
- Middle Aged
- Oxidative Stress
- Proteinuria
(prevention & control)
- Time Factors
- Wine
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