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[Amiodarone-induced pulmonary toxicity].

Abstract
Amiodarone is highly effective in suppressing ventricular and supraventricular tachyarrhythmias. The most serious adverse reaction is pulmonary toxicity. The mechanisms involved in amiodarone-induced pulmonary injury are incompletely understood. Several forms of pulmonary disease occur including interstitial pneumonitis, fibrosis or organizing pneumonia. The incidence is generally lower with lower maintenance doses (<or= 300 mg/d). There are no adequate predictors of pulmonary toxicity due to amiodarone. The diagnosis of amiodarone-induced pulmonary toxicity is one of exclusion. Treatment consists primarily of stopping amiodarone application. Corticosteroid therapy can be life-saving for severe cases and for patients in whom withdrawl of amiodarone is not possible.
AuthorsA Heisel, M Berg, M Stopp, D Ukena, H Schieffer
JournalMedizinische Klinik (Munich, Germany : 1983) (Med Klin (Munich)) Vol. 92 Suppl 5 Pg. 33-6 (Dec 1997) ISSN: 1615-6722 [Electronic] Germany
Vernacular TitleAmiodaroninduzierte Lungenveränderungen.
PMID19479394 (Publication Type: English Abstract, Journal Article, Review)
Chemical References
  • Anti-Arrhythmia Agents
  • Amiodarone
Topics
  • Amiodarone (adverse effects, therapeutic use)
  • Anti-Arrhythmia Agents (adverse effects, therapeutic use)
  • Bronchial Spasm (chemically induced)
  • Controlled Clinical Trials as Topic
  • Cryptogenic Organizing Pneumonia (chemically induced)
  • Diagnosis, Differential
  • Dose-Response Relationship, Drug
  • Humans
  • Lung Diseases, Interstitial (chemically induced)
  • Pleural Diseases (chemically induced)
  • Prognosis
  • Pulmonary Fibrosis (chemically induced)
  • Risk Factors
  • Tachycardia, Supraventricular (drug therapy)
  • Tachycardia, Ventricular (drug therapy)

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