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Marked iron overload related to ribavirin and iron sulfate treatment in a patient with active viral C cirrhosis.

Abstract
Increased ferritin levels are common in the course of chronic hepatitis C, regardless of antiviral therapy. Usually, this increase in ferritin levels has minimal clinical and biological impact, and drops after therapy discontinuation. We report here on a dramatic increase in ferritin levels in a cirrhotic patient with hepatitis C treated by ribavirin monotherapy and oral iron sulphate, and discuss the possible mechanisms of this deleterious effect.
AuthorsVincent Jouannaud, Jean-François Cadranel, Patrice Dumouchel, Alain Cazier, Dominique Capron, Jacques Rochette, Jean-Claude Barbare
JournalEuropean journal of gastroenterology & hepatology (Eur J Gastroenterol Hepatol) Vol. 21 Issue 11 Pg. 1310-3 (Nov 2009) ISSN: 1473-5687 [Electronic] England
PMID19478679 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antiviral Agents
  • Ferrous Compounds
  • ferrous sulfate
  • Ribavirin
  • Ferritins
Topics
  • Antiviral Agents (adverse effects)
  • Drug Therapy, Combination
  • Female
  • Ferritins (blood)
  • Ferrous Compounds (adverse effects)
  • Hepatitis C, Chronic (blood, drug therapy)
  • Humans
  • Iron Overload (chemically induced)
  • Middle Aged
  • Ribavirin (adverse effects)

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