Drug hypersensitivity syndrome induced by meglumine antimoniate.

Abstract

We report a case of drug hypersensitivity syndrome (drug reaction with eosinophilia and systemic symptoms [DRESS]) induced by parenteral meglumine antimoniate (Glucantime) in a 40-year-old man who traveled to Bolivia and was treated for mucocutaneous leishmaniasis. Two weeks after starting therapy, the patient had fever, joint pain, a cutaneous eruption, and hypereosinophilia (1,358 cells/mm(3)). These symptoms resolved after drug withdrawal but reappeared upon reintroduction of the drug. Pentavalent antimonials should be definitively withdrawn in patients with hypereosinophilia > 1,000 cells/mm(3) accompanied by systemic manifestations consistent with DRESS.

• Authors: Fakhri Jeddi, Eric Caumes, Marc Thellier, Stéphane Jauréguiberry, Dominique Mazier, Pierre A Buffet
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 80 Issue 6 Pg. 939-40 (Jun 2009) ISSN: 1476-1645 [Electronic] United States
• PMID: 19478253 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antiprotozoal Agents
• Organometallic Compounds
• Meglumine
• Meglumine Antimoniate

Topics

• Adult
• Antiprotozoal Agents (administration & dosage, adverse effects, therapeutic use)
• Drug Hypersensitivity
• Humans
• Leishmaniasis, Mucocutaneous (drug therapy)
• Male
• Meglumine (administration & dosage, adverse effects, therapeutic use)
• Meglumine Antimoniate
• Organometallic Compounds (administration & dosage, adverse effects, therapeutic use)
• Syndrome