Chemical constituents from the aerial parts of Artemisia minor.

Abstract

Four new compounds including three bicoumarins, arteminorins A-C (1-3), and one neolignan, arteminorin D (4), together with 31 known ones were isolated from the aerial parts of Artemisia minor. Their structures were established on the basis of spectroscopic data and comparison with those of the related known compounds. Ethyl caffeate (27) showed in vitro cytotoxicity against the HepG2 cancer cell line. Arteminorin C (3) and luteolin (19) showed inhibitory activity on xanthine oxidase (XOD), and caffeic acid (28) exhibited inhibitory activity on protein tyrosine phosphatase 1B (PTP1B).

• Authors: Zhi-Zhou He, Ju-Fang Yan, Zhi-Jun Song, Fei Ye, Xun Liao, Shu-Lin Peng, Li-Sheng Ding
• Journal: Journal of natural products (J Nat Prod) Vol. 72 Issue 6 Pg. 1198-201 (Jun 2009) ISSN: 1520-6025 [Electronic] United States
• PMID: 19476336 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Caffeic Acids
• Coumarins
• Drugs, Chinese Herbal
• Lignans
• arteminorin A
• arteminorin B
• arteminorin C
• arteminorin D
• Xanthine Oxidase
• Protein Tyrosine Phosphatase, Non-Receptor Type 1

Topics

• Artemisia (chemistry)
• Caffeic Acids (pharmacology)
• Coumarins (chemistry, isolation & purification, pharmacology)
• Drugs, Chinese Herbal (chemistry, isolation & purification, pharmacology)
• Electron Spin Resonance Spectroscopy
• Humans
• Lignans (chemistry, isolation & purification, pharmacology)
• Molecular Structure
• Plants, Medicinal (chemistry)
• Protein Tyrosine Phosphatase, Non-Receptor Type 1 (antagonists & inhibitors)
• Tibet
• Xanthine Oxidase (antagonists & inhibitors)