Induction of neuronal differentiation in neurosphere stem cells by ellagic acid derivatives.

Abstract

A bioassay-guided fractionation of methanol extracts of stem barks, combined with screening based on Epidermal Growth Factor (EGF)-responsive neural stem cells (erNSCs) differentiation assay, has been used. This study resulted in the isolation of 3,3'-di-O-methylellagic acid 1, 3,3'-di-O-methyl ellagic acid-4-O-beta-D-xylopyranoside 2, ellagic acid 3, and arjunolic acid 4. Among them, compounds 1 and 2 exhibit potent induction of neuronal differentiation in neurosphere stem cells with no cytotoxic effect. These results indicate that compounds 1 and 2 may be useful as pharmacological agents for the treatment of neurodegenerative diseases. These compounds may account, for the use of T. superba in folk medicine for nervous system and mental disorders.

• Authors: Turibio Kuiate Tabopda, Joseph Ngoupayo, Jia Wei Liu, Anne-Claire Mitaine-Offer, Bonaventure Tchaleu Ngadjui, Marie-Aleth Lacaille-Dubois, Bang Luu
• Journal: Natural product communications (Nat Prod Commun) Vol. 4 Issue 4 Pg. 517-20 (Apr 2009) ISSN: 1934-578X [Print] United States
• PMID: 19475997 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ellagic Acid

Topics

• Animals
• Cell Differentiation (drug effects)
• Cells, Cultured
• Chemical Fractionation
• Ellagic Acid (analogs & derivatives, chemistry, isolation & purification, pharmacology)
• Mice
• Neurons (cytology, drug effects)
• Stem Cells (cytology, drug effects)
• Terminalia (chemistry)