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Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice.

Abstract
We examined anti-amnesic activity of the methanolic extract of Cornus officinalis fruits (COT) and a major constituent, loganin using scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and the Morris water maze tests. Oral treatment of mice with COT (100 mg/kg body weight) and loganin (1 and 2 mg/kg body weight) significantly mitigated scopolamine-induced memory deficits in passive avoidance test. In the Morris water maze test, oral treatment of loganin significantly ameliorated scopolamine-induced memory deficits showing the formation of long-term and/or short-term spatial memory. Moreover, loganin (2 mg/kg body weight) significantly inhibited acetylcholinesterase activity by as much as 45% of control in the mouse hippocampus. These results indicate that loganin may exert antiamnesic activity in in vivo through acetylcholinesterase inhibition.
AuthorsKi Yong Lee, Sang Hyun Sung, Seung Hyun Kim, Young Pyo Jang, Tae Hwan Oh, Young Choong Kim
JournalArchives of pharmacal research (Arch Pharm Res) Vol. 32 Issue 5 Pg. 677-83 (May 2009) ISSN: 0253-6269 [Print] Korea (South)
PMID19471881 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cholinesterase Inhibitors
  • Iridoids
  • Nootropic Agents
  • Scopolamine
  • Acetylcholinesterase
  • loganin
Topics
  • Acetylcholinesterase (metabolism)
  • Administration, Oral
  • Amnesia (chemically induced, drug therapy, enzymology, psychology)
  • Animals
  • Avoidance Learning (drug effects)
  • Behavior, Animal (drug effects)
  • Cholinesterase Inhibitors (administration & dosage, isolation & purification, pharmacology)
  • Cognition (drug effects)
  • Cornus (chemistry)
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Fruit
  • Hippocampus (drug effects, enzymology)
  • Iridoids (administration & dosage, isolation & purification, pharmacology)
  • Male
  • Memory, Short-Term (drug effects)
  • Mice
  • Mice, Inbred ICR
  • Nootropic Agents (administration & dosage, isolation & purification, pharmacology)
  • Scopolamine
  • Time Factors

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