| Abstract | CONTEXT: Chemerin is a novel adipokine previously associated with metabolic syndrome phenotypes in a small sample of subjects from Mauritius. OBJECTIVE: The aim of the study was to determine whether plasma chemerin levels were associated with metabolic syndrome phenotypes in a larger sample from a second, unrelated human population. DESIGN, SETTING, PATIENTS, AND INTERVENTION: Plasma samples were obtained from the San Antonio Family Heart Study (SAFHS), a large family-based genetic epidemiological study including 1431 Mexican-American individuals. Individuals were randomly sampled without regard to phenotype or disease status. This sample is well-characterized for a variety of phenotypes related to the metabolic syndrome. MAIN OUTCOMES: Plasma chemerin levels were measured by sandwich ELISA. Linear regression and correlation analyses were used to determine associations between plasma chemerin levels and metabolic syndrome phenotypes. RESULTS: Circulating chemerin levels were significantly higher in nondiabetic subjects with body mass index (BMI) greater than 30 kg/m(2) compared with those with a BMI below 25 kg/m(2) (P < 0.0001). Plasma chemerin levels were significantly associated with metabolic syndrome-related parameters, including BMI (P < 0.0001), fasting serum insulin (P < 0.0001), triglycerides (P < 0.0001), and high-density lipoprotein cholesterol (P = 0.00014), independent of age and sex in nondiabetic subjects. CONCLUSION: Circulating chemerin levels were associated with metabolic syndrome phenotypes in a second, unrelated human population. This replicated result using a large human sample suggests that chemerin may be involved in the development of the metabolic syndrome. |
| Authors | Kiymet Bozaoglu, David Segal, Katherine A Shields, Nik Cummings, Joanne E Curran, Anthony G Comuzzie, Michael C Mahaney, David L Rainwater, John L VandeBerg, Jean W MacCluer, Greg Collier, John Blangero, Ken Walder, Jeremy B M Jowett
(Affiliation: Metabolic Research Unit, Deakin University, Pigdons Road, Waurn Ponds, Victoria 3218, Australia.)
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| Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 94
Issue 8
Pg. 3085-8
(Aug 2009)
ISSN: 1945-7197 [Electronic] United States |
| PMID | 19470637
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Chemokines
- chemerin, human
|
| Topics |
- Adult
- Aged
- Chemokines
(blood, physiology)
- Diabetes Mellitus, Type 2
(blood)
- Female
- Humans
- Male
- Metabolic Syndrome X
(blood, ethnology)
- Mexican Americans
- Middle Aged
- Obesity
(blood)
- Overweight
(blood)
- Phenotype
|
