HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Prevention of itching after spinal sufentanil: effects of droperidol, nalbuphine, ondansetron and the association of them.].

AbstractBACKGROUND AND OBJECTIVES:
Spinal opioids may cause some undesirable effects, the most frequent of which is itching. In spite of its low morbidity rate, itching may cause severe discomfort to patients in addition to prolonging hospital stay. This study aimed at evaluating different therapeutic options to prevent itching after spinal sufentanil.
METHODS:
Participated in these study 100 patients scheduled for non-obstetric procedures, who were randomly distributed in five groups: control (no treatment - C); 2.5 mg droperidol (D); 10 mg nalbuphine (N); association of previous drugs (DN); and 8 mg ondansetron (O). Pruritus was quantitatively evaluated at 30 minutes, 1, 2 and 3 hours after spinal sufentanil.
RESULTS:
Groups C and O had significantly higher incidence of itching as compared to groups D, N and DN. However, there has been no significant difference in the need for specific treatment with naloxone among groups.
CONCLUSIONS:
Itching prevention in our study, regardless of the drug used, has decreased its severity and has limited the need for specific treatment with naloxone.
AuthorsAndré Kolm, Alexandre Alberto Fontana Ferraz, Norma Sueli Pinheiro Módolo, Fábio Ferrari, Eliana Marisa Ganem, Geraldo Rolim Rodrigues Júnior, Paulo do Nascimento Júnior, Giane Nakamura, Lais Helena Camacho Navarro, Rodrigo Moreira Lima
JournalRevista brasileira de anestesiologia (Rev Bras Anestesiol) Vol. 56 Issue 1 Pg. 28-33 (Feb 2006) ISSN: 1806-907X [Electronic] Brazil
Vernacular TitleProfilaxia do prurido causado pela administração subaracnóidea de sufentanil: efeitos do droperidol, da nalbufina, do ondansetron e da combinação deles.
PMID19468547 (Publication Type: English Abstract, Journal Article)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: