Abstract | OBJECTIVE: METHODS: RESULTS: An antecedent stressful event was identified in 15 ABS patients. There were no differences in plasma normetanephrine (median 0.64 (IQ range 0.43-0.97) nmol/l vs 0.53 (0.32-0.77) nmol/l, p = 0.44), metanephrine (0.10 (0.10-0.22) nmol/l vs 0.16 (0.10-0.38) nmol/l, p = 0.29), or cortisol levels (16.0 (7.3-44.0) microg/dl vs 13.0 (10.5-23.5) microg/dl, p = 0.95) between ABS and STEMI patients. The 24-hour urine metanephrines, catecholamines and cortisol levels were normal in the majority of ABS patients. Troponin T levels were lower (0.62 (0.18-0.84) ng/ml vs 3.80 (2.04-6.57) ng/ml, p<0.001), but BNP levels were higher in ABS compared with STEMI (944 (650-2022) pg/ml vs 206 (140-669) pg/ml, p = 0.009). HsCRP was similarly elevated in the two groups (11.0 (5.1-110.8) mg/l and 24.3 (8.1-88.6) mg/l, p = 0.78). CONCLUSIONS:
Catecholamine and cortisol levels were not elevated in our cohort of ABS, suggesting that routine measurement of these stress hormones is unlikely to be of diagnostic value in practice. In contrast to STEMI, ABS is characterised by a greater elevation in BNP and less myonecrosis.
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Authors | M Madhavan, B A Borlaug, A Lerman, C S Rihal, A Prasad |
Journal | Heart (British Cardiac Society)
(Heart)
Vol. 95
Issue 17
Pg. 1436-41
(Sep 2009)
ISSN: 1468-201X [Electronic] England |
PMID | 19468013
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Biomarkers
- Troponin T
- Natriuretic Peptide, Brain
- C-Reactive Protein
- Dopamine
- Norepinephrine
- Epinephrine
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers
(blood, urine)
- C-Reactive Protein
(metabolism)
- Case-Control Studies
- Coronary Angiography
- Dopamine
(metabolism)
- Epinephrine
(metabolism)
- Female
- Hemodynamics
- Humans
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Norepinephrine
(metabolism)
- Takotsubo Cardiomyopathy
(diagnosis, diagnostic imaging, physiopathology)
- Troponin T
(blood)
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