Abstract | PURPOSE: To investigate the safety and efficacy of intraoperative infiltration of 5-fluorouracil (5-FU) as an adjuvant drug in pterygium treatment. METHODS: Of 125 consecutive patients, 125 eyes with primary and recurrent pterygium underwent pterygium excision with intraoperative 5-FU (25 mg/mL) infiltration. The superior and inferior conjunctiva was approximated to cover the scleral bed and 0.2 mL 5-FU was injected at the end of the surgical procedure. The gender, occupation, pterygium characteristics and the follow-up at 7, 21, 60 e 180 days after surgery were evaluated and the data were statistically analyzed. RESULTS: With follow-up of 180 days the patients had no serious complications observed during or after surgery. The relapse rate was 35.8% and occurred in primary (35.7%) and recurrent (36.4%) lesions with no statistical difference. CONCLUSIONS: This study suggests that intraoperative infiltration of 5-FU is safe. However the high recurrence rate indicated that other studies would be necessary to show the concentration/dose to better prevent it.
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Authors | Vanessa Grandi Valezi, Silvana Artioli Schellini, Magda Massae Hata Viveiros, Carlos Roberto Padovani |
Journal | Arquivos brasileiros de oftalmologia
(Arq Bras Oftalmol)
2009 Mar-Apr
Vol. 72
Issue 2
Pg. 169-73
ISSN: 1678-2925 [Electronic] Brazil |
Vernacular Title | Segurança e efetividade no tratamento do pterígio usando infiltração de 5-fluoruracila no intraoperatório. |
PMID | 19466323
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Immunosuppressive Agents
- Fluorouracil
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Topics |
- Adult
- Female
- Fluorouracil
(administration & dosage, adverse effects)
- Follow-Up Studies
- Humans
- Immunosuppressive Agents
(administration & dosage, adverse effects)
- Intraoperative Care
- Male
- Middle Aged
- Prospective Studies
- Pterygium
(drug therapy, surgery)
- Secondary Prevention
- Treatment Outcome
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