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[Safety and efficacy of intraoperative 5-fluorouracil infiltration in pterygium treatment].

AbstractPURPOSE:
To investigate the safety and efficacy of intraoperative infiltration of 5-fluorouracil (5-FU) as an adjuvant drug in pterygium treatment.
METHODS:
Of 125 consecutive patients, 125 eyes with primary and recurrent pterygium underwent pterygium excision with intraoperative 5-FU (25 mg/mL) infiltration. The superior and inferior conjunctiva was approximated to cover the scleral bed and 0.2 mL 5-FU was injected at the end of the surgical procedure. The gender, occupation, pterygium characteristics and the follow-up at 7, 21, 60 e 180 days after surgery were evaluated and the data were statistically analyzed.
RESULTS:
With follow-up of 180 days the patients had no serious complications observed during or after surgery. The relapse rate was 35.8% and occurred in primary (35.7%) and recurrent (36.4%) lesions with no statistical difference.
CONCLUSIONS:
This study suggests that intraoperative infiltration of 5-FU is safe. However the high recurrence rate indicated that other studies would be necessary to show the concentration/dose to better prevent it.
AuthorsVanessa Grandi Valezi, Silvana Artioli Schellini, Magda Massae Hata Viveiros, Carlos Roberto Padovani
JournalArquivos brasileiros de oftalmologia (Arq Bras Oftalmol) 2009 Mar-Apr Vol. 72 Issue 2 Pg. 169-73 ISSN: 1678-2925 [Electronic] Brazil
Vernacular TitleSegurança e efetividade no tratamento do pterígio usando infiltração de 5-fluoruracila no intraoperatório.
PMID19466323 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Immunosuppressive Agents
  • Fluorouracil
Topics
  • Adult
  • Female
  • Fluorouracil (administration & dosage, adverse effects)
  • Follow-Up Studies
  • Humans
  • Immunosuppressive Agents (administration & dosage, adverse effects)
  • Intraoperative Care
  • Male
  • Middle Aged
  • Prospective Studies
  • Pterygium (drug therapy, surgery)
  • Secondary Prevention
  • Treatment Outcome

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