Accidental acute clidinium toxicity.

Abstract

Clidinium bromide (N-methyl-quinuclidinyl-benzylate) is a rarely used antimuscarinic drug that is marketed in combination with chlordiazepoxide as an antispasmodic for use in irritable bowel syndrome. A case is reported of an accidental staggered overdose of clidinium bromide 50 mg in a patient using illicit chlordiazepoxide. The presenting features were mildly dilated pupils and palpitation secondary to sinus tachycardia that persisted for 11 h after the time of first ingestion. Emergency physicians should be aware of the potential for antimuscarinic toxicity in patients using illicit chlordiazepoxide.

• Authors: S E Richardson, K Edwards
• Journal: Emergency medicine journal : EMJ (Emerg Med J) Vol. 26 Issue 6 Pg. 460 (Jun 2009) ISSN: 1472-0213 [Electronic] England
• PMID: 19465630 (Publication Type: Case Reports, Journal Article)

Chemical References

• Illicit Drugs
• Parasympatholytics
• Quinuclidinyl Benzilate
• Chlordiazepoxide
• clidinium

Topics

• Acute Disease
• Adult
• Chlordiazepoxide (poisoning)
• Humans
• Illicit Drugs (poisoning)
• Male
• Mydriasis (chemically induced)
• Parasympatholytics (poisoning)
• Quinuclidinyl Benzilate (analogs & derivatives, poisoning)
• Tachycardia, Sinus (chemically induced)