[Micafungin for the treatment of neonatal invasive candidiasis].

Abstract

BACKGROUND:

In neonatal intensive care units, deep fungal disease due to Candida spp. are an important clinical problem, partly due to the increasing prevalence of Candida disease and also to the high associated and constant morbimortality; both factors are independently maintained though there has been a significant improvement in the management of neonatal patients.

AIMS:

To define the therapeutic use of micafungin for the treatment of neonatal invasive candidiasis.

METHODS:

We use a review of biomedic data bases namely Medline and EMBASE.

CONCLUSIONS:

Micafungin is the latest introduced echinocandin. It has a wide spectrum of activity and covers Candida albicans and non-albicans Candida species. It has scarce drugs interactions and is devoid of toxicity, being an attractive approach for the treatment of invasive candidiasis (without meningitis, endocarditis and endophthalmitis). Althought the European Medicines Agency approved in 2008 the use of Micafungin for the treatment of invasive candidiasis in children, the available clinical experience is limited and currently more clinical studies are warranted to define its efficacy and safety in neonates.

• Authors: María Elena Infante-López, Pablo Rojo-Conejo
• Journal: Revista iberoamericana de micologia (Rev Iberoam Micol) Vol. 26 Issue 1 Pg. 56-61 (Mar 31 2009) ISSN: 1130-1406 [Print] Spain
• Vernacular Title: Utilidad clínica de la micafungina en el tratamiento de las candidiasis invasoras en el neonato.
• PMID: 19463278 (Publication Type: Comparative Study, Journal Article, Review)

Chemical References

• Antifungal Agents
• Echinocandins
• Lipopeptides
• liposomal amphotericin B
• Amphotericin B
• Micafungin

Topics

• Adolescent
• Adult
• Age Factors
• Amphotericin B (therapeutic use)
• Antifungal Agents (therapeutic use)
• Candidiasis (drug therapy)
• Child
• Child, Preschool
• Clinical Trials as Topic (statistics & numerical data)
• Echinocandins (therapeutic use)
• Female
• Fungemia (drug therapy)
• Humans
• Infant
• Infant, Newborn
• Infant, Premature
• Infant, Premature, Diseases (drug therapy, microbiology)
• Lipopeptides (therapeutic use)
• Male
• Meta-Analysis as Topic
• Micafungin
• Multicenter Studies as Topic (statistics & numerical data)
• Prospective Studies
• Randomized Controlled Trials as Topic (statistics & numerical data)
• Retrospective Studies