Abstract |
Splenectomy indications and outcome were evaluated in 124 adults with hemoglobin SC disease (Hb SC). Twelve patients (9.6%) required splenectomy. There was a significant difference between the splenectomy group and the non- splenectomy group, respectively, regarding Hb levels (median 7.2 g/dL vs. 12.5 g/dL, P < 0.0001), platelet counts (median 146 x 10(6)/L vs. 275 x 10(6)/L, P = 0.031), palpable spleen rate (66% vs. 16%, P = 0.0003%), acute chest syndrome frequency (75% vs. 12%P = 0.0004) and cholecystectomy rate (66% vs. 13%, P = 0.0004). No significant morbidity or mortality occurred postsplenectomy. There is a subgroup of Hb SC patients requiring splenectomy, in which splenectomy is effective. Although it appears to be safe regarding short-term complications of surgery, long-term adverse effects such as infections have to be evaluated cautiously.
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Authors | Karthi Subbannan, Celalettin Ustun, Kavita Natarajan, Betsy Clair, Lisa Daitch, Sabine Fields, Ferdane Kutlar, Abdullah Kutlar |
Journal | European journal of haematology
(Eur J Haematol)
Vol. 83
Issue 3
Pg. 258-60
(Sep 2009)
ISSN: 1600-0609 [Electronic] England |
PMID | 19459924
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Adult
- Aged
- Female
- Hemoglobin SC Disease
(complications, surgery)
- Humans
- Male
- Middle Aged
- Platelet Count
- Retrospective Studies
- Sickle Cell Trait
(complications, diagnosis)
- Splenectomy
(methods)
- Splenic Diseases
(complications, diagnosis)
- Thrombocytopenia
(diagnosis)
- Treatment Outcome
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