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Acute splenic complications and implications of splenectomy in hemoglobin SC disease.

Abstract
Splenectomy indications and outcome were evaluated in 124 adults with hemoglobin SC disease (Hb SC). Twelve patients (9.6%) required splenectomy. There was a significant difference between the splenectomy group and the non-splenectomy group, respectively, regarding Hb levels (median 7.2 g/dL vs. 12.5 g/dL, P < 0.0001), platelet counts (median 146 x 10(6)/L vs. 275 x 10(6)/L, P = 0.031), palpable spleen rate (66% vs. 16%, P = 0.0003%), acute chest syndrome frequency (75% vs. 12%P = 0.0004) and cholecystectomy rate (66% vs. 13%, P = 0.0004). No significant morbidity or mortality occurred postsplenectomy. There is a subgroup of Hb SC patients requiring splenectomy, in which splenectomy is effective. Although it appears to be safe regarding short-term complications of surgery, long-term adverse effects such as infections have to be evaluated cautiously.
AuthorsKarthi Subbannan, Celalettin Ustun, Kavita Natarajan, Betsy Clair, Lisa Daitch, Sabine Fields, Ferdane Kutlar, Abdullah Kutlar
JournalEuropean journal of haematology (Eur J Haematol) Vol. 83 Issue 3 Pg. 258-60 (Sep 2009) ISSN: 1600-0609 [Electronic] England
PMID19459924 (Publication Type: Journal Article)
Topics
  • Adolescent
  • Adult
  • Aged
  • Female
  • Hemoglobin SC Disease (complications, surgery)
  • Humans
  • Male
  • Middle Aged
  • Platelet Count
  • Retrospective Studies
  • Sickle Cell Trait (complications, diagnosis)
  • Splenectomy (methods)
  • Splenic Diseases (complications, diagnosis)
  • Thrombocytopenia (diagnosis)
  • Treatment Outcome

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