Abstract | INTRODUCTION: OBJECTIVE: To evaluate the oxidative stress in patients with DM type 2, particularly with LVDD and hypertension and to determine the influence of acute exercise training on the investigated parameters. METHODS: RESULTS: In basal conditions, diabetic patients had a significant increase of TG (3.12 +/- 1.09 vs 1.74 +/- 0.9 mmol/l; p < 0.01), OxLDL cholesterol (84.73 +/- 16.9 vs 79.00 +/- 29.26 mmol/l; p < 0.05) and SOD enzyme activity (913.38 +/- 120.36 vs 877.14 +/- 153.18; p < 0.05) compared to controls. During the acute exercise test, there were significantly greater levels of OxLDL (84.73 +/- 16.90 vs 92.33 +/- 23.29 mmol/l; p < 0.05) in study patients. SOD significantly increased in both groups during exercise, in diabetic patients (913.38 +/- 120.36 vs 921.50 +/- 130.03 U/g Hb; p < 0.05) and in controls (877.14 +/- 153.18 vs 895.00 +/- 193.49 U/g Hb; p < 0.05). GSH-Px significantly increased only in diabetic patients after acute exercise (45.04 +/- 11.19 vs 51.81 +/- 15.07 U/g Hb; p < 0.01), but not in controls. PAI significantly decreased during the exercise test only in healthy subjects (2.60 +/- 0.35 vs 2.22 +/- 0.65; p < 0.05). Type 2 diabetic patients with cardiovascular complications (LVDD and hypertension) had a significant increase of GSH-Px activity (47.10 +/- 7.37 vs 54.52 +/- 11.97 U/g Hb; p < 0.01). CONCLUSION: Elevated enzyme levels are associated with exercise in type 2 diabetic patients. We suggest that it could be a compensatory mechanism to prevent free radical tissue damage. We hypothesize that a physical training programme induces the enhancement of muscular and liver antioxidant enzymes and reduces the oxidative stress.
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Authors | Nada Kostić, Zorica Caparavić, Sanja Ilić, Jana Radojković, Djordje Marina, Biljana Pencić, Milica Dekleva |
Journal | Srpski arhiv za celokupno lekarstvo
(Srp Arh Celok Lek)
2009 Mar-Apr
Vol. 137
Issue 3-4
Pg. 146-51
ISSN: 0370-8179 [Print] Serbia |
PMID | 19459560
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antioxidants
- Plasminogen Activator Inhibitor 1
- Glutathione Peroxidase
- Superoxide Dismutase
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Topics |
- Antioxidants
(metabolism)
- Diabetes Mellitus, Type 2
(complications, enzymology, metabolism)
- Diastole
- Exercise Test
- Female
- Glutathione Peroxidase
(blood)
- Humans
- Hypertension
(complications)
- Male
- Middle Aged
- Oxidative Stress
- Plasminogen Activator Inhibitor 1
(blood)
- Superoxide Dismutase
(blood)
- Ventricular Dysfunction, Left
(complications)
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