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[Efficacy of ingavirin in adults with influenza].

AbstractAIM:
To compare therapeutic efficacy and safety of ingavirin and arbidol in patients with influenza.
MATERIAL AND METHODS:
The trial included 105 patients with a verified diagnosis of influenza, definite clinical symptoms, body temperature at least 38 degrees C and duration of the disease 36 hours maximum. Ingavirin efficacy was analysed basing on the evidence for 100 patients with uncomplicated influenza. The patients were randomized into three groups: taking ingavirin in a single daily dose 90 mg (n = 33), placebo (n = 36) or arbidol (200 mg 4 times a day). The duration of the treatment was 5 days.
RESULTS:
Intake of ingavirin in initial 24-36 hours of the disease significantly reduced fever compared to placebo and arbidol (34.5, 72.0 and 48.4 hours, respectively). Ingavirin was less toxic and had no side effects.
CONCLUSION:
Ingavirin is safe and effective in the treatment of influenza. By some criteria it is more effective than arbidol.
AuthorsL V Kolobukhina, L N Merkulova, M Iu Shchelkanov, E I Burtseva, E I Isaeva, N A Malyshev, D K L'vov
JournalTerapevticheskii╠ć arkhiv (Ter Arkh) Vol. 81 Issue 3 Pg. 51-4 ( 2009) ISSN: 0040-3660 [Print] Russia (Federation)
PMID19459424 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
Chemical References
  • 6-(2-(1H-imidazol-4-yl)ethylamino)-5-oxohexanoic acid
  • Amides
  • Antiviral Agents
  • Caproates
  • Dicarboxylic Acids
  • Imidazoles
  • Indoles
  • arbidol
Topics
  • Adolescent
  • Adult
  • Amides (administration & dosage, adverse effects)
  • Antiviral Agents (administration & dosage, adverse effects)
  • Caproates
  • Dicarboxylic Acids (administration & dosage, adverse effects)
  • Female
  • Humans
  • Imidazoles (administration & dosage, adverse effects)
  • Indoles (administration & dosage, adverse effects)
  • Influenza, Human (drug therapy)
  • Male
  • Middle Aged
  • Young Adult

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