Caffeic acid phenethyl ester prevents ovary ischemia/reperfusion injury in rabbits.

Abstract

Protective effect of caffeic acid phenethyl ester (CAPE) on ovary ischemia/reperfusion (IR) injury was investigated in this study. Twenty four New Zealand rabbits were divided into 4 groups as follows: group S served as sham. Group C was intraperitoneally injected with CAPE (8.5mg/kg). In groups E+IR and C+IR, 1% ethanol and CAPE was given intraperitoneally before torsion, respectively. Then, the ovaries were subjected to IR in both groups. Ovary reduced glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity in group E+IR were significantly reduced compared to that of group S. GSH level and GSH-Px activity was significantly increased in group C+I/R. Thiobarbituric acid reactive substances (TBARS) and catalase (CAT) activity in group E+I/R was significantly higher than in group S. CAT activity was decreased to normal levels by CAPE treatment in group C+I/R, while TBARS in group C+IR was significantly reduced compared to that of E+IR. According to histopathological examination, severe congestion, hemorrhage, edema and leukocyte infiltration were observed in E+I/R group. CAPE prominently reduced degenerative effects of IR injury thus it alleviates free radical damage. In conclusion, CAPE which is able to prevent IR-induced injury in the ovaries may be of therapeutic value before the surgical correction.

• Authors: A Kart, Y Cigremis, H Ozen, O Dogan
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 47 Issue 8 Pg. 1980-4 (Aug 2009) ISSN: 1873-6351 [Electronic] England
• PMID: 19457442 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Caffeic Acids
• Thiobarbituric Acid Reactive Substances
• Catalase
• caffeic acid phenethyl ester
• Glutathione
• Phenylethyl Alcohol

Topics

• Animals
• Antioxidants (metabolism)
• Caffeic Acids (toxicity)
• Catalase (metabolism)
• Female
• Glutathione (metabolism)
• Lipid Peroxidation (drug effects)
• Ovarian Diseases (prevention & control)
• Phenylethyl Alcohol (analogs & derivatives, toxicity)
• Rabbits
• Reperfusion Injury (prevention & control)
• Thiobarbituric Acid Reactive Substances (metabolism)