[Mucoid impaction of the bronchi caused by Schizophyllum commune which developed after discontinuation of itraconazole administration].

Abstract

We report the case of a 75-year-old woman with mucoid impaction of the bronchi (MIB) due to Schizophyllum commune who improved with itraconazole (ITCZ) administration and relapsed after discontinuation of the drug. She improved again after readministration of ITCZ, and MIB has not recurred. This patient was not suffering from asthma and has been well without steroid administration. Reports of respiratory disorders due to S. commune have been increasing, and cases of allergic bronchopulmonary mycosis (ABPM), fungus ball, lung abscess, and pneumonia have been reported. Including this report, 12 cases of ABPM and MIB due to S. commune have been reported by Japanese authors. Treatment in these 12 cases included anti-fungal agent in 6, single steroid therapy in 3, combination therapy in 2, and bronchial toilet in 1 case. S. commune is not well recognized; however, one should suspect this fungus to be the causative pathogen when Aspergillus species are not detected or anti-Aspergillus antibody is negative.

• Authors: Takashi Ishiguro, Noboru Takayanagi, Keiji Harasaw, Yutaka Yoshii, Aya Matsushita, Koichiro Yoneda, Yousuke Miyahara, Naho Kagiyama, Daido Tokunaga, Fumiaki Aoki, Hiroo Saito, Mikio Ubukata, Kazuyoshi Kurashima, Tsutomu Yanagisawa, Yutaka Sugita, Yoshinori Kawabata, Katsuhiko Kamei
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 47 Issue 4 Pg. 296-303 (Apr 2009) ISSN: 1343-3490 [Print] Japan
• PMID: 19455959 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Itraconazole

Topics

• Aged
• Bronchial Diseases (drug therapy, etiology)
• Female
• Humans
• Itraconazole (administration & dosage)
• Lung Diseases, Fungal (drug therapy)
• Recurrence
• Schizophyllum