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In vivo pharmacokinetics comparisons of icariin, emodin and psoralen from gan-kang granules and extracts of herba Epimedii, Nepal dock root, Ficus hirta yahl.

AbstractETHNOPHARMACOLOGICAL RELEVANCE:
Gan-kang granules (GKG) contains the extracts from eight Chinese herbs and is a traditional Chinese composite prescription for treatment of hepatitis B. Icariin, emodin and psoralen are main effective ingredients of the medicine.
AIM OF THE STUDY:
In this research, pharmacokinetic comparisons of icariin, emodin and psoralen from the extracts of herba Epimedii, Nepal dock root and Ficus hirta yahl, and GKG were conducted.
MATERIALS AND METHODS:
At different time points (0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12 and 24 h) after administration, the concentrations of icariin, emodin and psoralen in rat plasma were determined by HPLC-UV, and main pharmacokinetic parameters were estimated.
RESULTS:
The pharmacokinetic parameters of icariin, emodin and psoralen in GKG were elevated comparing with those of herb extracts.
CONCLUSIONS:
Three HPLC-UV methods were developed successfully for the analysis of icariin, emodin and psoralen in SD rat plasma. Some ingredients in GKG may increase the dissolution and absorption, and improve bioavailability of icariin, emodin and psoralen in rats.
AuthorsYihui Li, Juping Duan, Tingting Guo, Wei Xie, Shineng Yan, Bo Li, Yanqin Zhou, Yuxiang Chen
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 124 Issue 3 Pg. 522-9 (Jul 30 2009) ISSN: 1872-7573 [Electronic] Ireland
PMID19454311 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drugs, Chinese Herbal
  • Flavonoids
  • Plant Extracts
  • epimedii flavone
  • gan-kang
  • Emodin
  • Ficusin
  • icariin
Topics
  • Animals
  • Calibration
  • Chromatography, High Pressure Liquid
  • Drug Stability
  • Drug Synergism
  • Drugs, Chinese Herbal (chemistry, pharmacology)
  • Emodin (pharmacokinetics)
  • Ficus (chemistry)
  • Ficusin (pharmacokinetics)
  • Flavonoids (pharmacokinetics)
  • Plant Extracts (pharmacokinetics)
  • Quality Control
  • Rats
  • Reference Standards
  • Reproducibility of Results
  • Rumex (chemistry)
  • Spectrophotometry, Ultraviolet

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