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The application of 19F magnetic resonance ex vivo imaging of three-dimensional cultured breast cancer cells to study the effect of delta-tocopherol.

Abstract
The aim of this study was to determine the role of delta-tocopherol in breast cancer cell growth ex vivo. Human gland mammary adenocarcinoma (MCF-7) and human T-lymphoblastoid (CEM) cells were cultured in the presence of delta-tocopherol at various concentrations (0-750 microM) for 5 days. We have grown 3D ex vivo breast cancer cell cultures in the hollow fiber bioreactor (HFBR). (19)F magnetic resonance imaging (MRI) was used to evaluate oxygen concentration in the cell suspension and thus its viability.
AuthorsDorota Bartusik, Boguslaw Tomanek, Danuta Siluk, Roman Kaliszan, Gino Fallone
JournalAnalytical biochemistry (Anal Biochem) Vol. 387 Issue 2 Pg. 315-7 (Apr 15 2009) ISSN: 1096-0309 [Electronic] United States
PMID19454246 (Publication Type: Journal Article)
Chemical References
  • Fluorine
  • delta-tocopherol
  • Tocopherols
  • Oxygen
Topics
  • Breast Neoplasms (pathology)
  • Cell Line, Tumor
  • Cell Survival (drug effects)
  • Female
  • Fluorine
  • Humans
  • Magnetic Resonance Imaging (methods)
  • Oxygen (analysis)
  • Tocopherols (pharmacology)

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