Abstract | BACKGROUND:
Apheresis donors are routinely evaluated with a complete blood count (CBC). Low red blood cell mean corpuscular volume (MCV) values (<80 fL) in the presence of an acceptable hemoglobin (Hb; >or=12.5 g/dL) could be due to iron deficiency or hemoglobinopathy. The etiology of a low MCV in a healthy apheresis donor population was assessed. METHODS: Predonation samples for CBC were obtained from 1162 consecutive apheresis donors. Donors with a MCV of less than 80 fL were evaluated by CBC, iron studies ( ferritin, serum iron, transferrin, percentage of transferrin saturation), and hemoglobin (Hb) electrophoresis. Iron deficiency was defined as a ferritin value below the reference range. Beta chain Hb variants were determined by Hb electrophoresis. Alpha thalassemia trait was presumed if the red blood cell (RBC) count was elevated, no variant Hbs were detected, and the iron studies were within normal ranges. RESULTS: CONCLUSION:
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Authors | Barbara J Bryant, Julie A Hopkins, Sarah M Arceo, Susan F Leitman |
Journal | Transfusion
(Transfusion)
Vol. 49
Issue 9
Pg. 1971-6
(Sep 2009)
ISSN: 1537-2995 [Electronic] United States |
PMID | 19453988
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Anemia, Iron-Deficiency
(etiology, metabolism)
- Blood Cell Count
- Blood Component Removal
(adverse effects)
- Blood Donors
- Erythrocyte Indices
- Erythrocytes
(cytology, metabolism)
- Female
- Hemoglobinopathies
(etiology, metabolism)
- Hemoglobins
(metabolism)
- Humans
- Male
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