Abstract |
The neuroprotective effects of newly developed oximes (K156, K203) and currently available oximes (obidoxime, HI-6) in combination with atropine in rats poisoned with cyclosarin were studied. The cyclosarin-induced neurotoxicity was monitored using a functional observational battery 24 hours after cyclosarin challenge. The results indicate that a newly developed oxime K156 is able to counteract slightly cyclosarin-induced neurotoxicity while another newly developed oxime K203 is completely ineffective in reducing cyclosarin-induced neurotoxic signs and symptoms. The neuroprotective efficacy of K156 is comparable with commonly used obidoxime and oxime HI-6. Thus, none of the newly developed oximes achieves better neuroprotective efficacy than both commonly used oximes. They are therefore not suitable replacements for antidotal treatment of acute poisonings with cyclosarin.
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Authors | Jirí Kassa, Jana Zd'árová Karasová, Sandra Tesarová, Kamil Kuca, Kamil Musílek |
Journal | Acta medica (Hradec Kralove)
(Acta Medica (Hradec Kralove))
Vol. 51
Issue 4
Pg. 215-21
( 2008)
ISSN: 1211-4286 [Print] Czech Republic |
PMID | 19453087
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chemical Warfare Agents
- Organophosphorus Compounds
- Oximes
- cyclohexyl methylphosphonofluoridate
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Topics |
- Animals
- Chemical Warfare Agents
(toxicity)
- Male
- Neurotoxicity Syndromes
(prevention & control)
- Organophosphorus Compounds
(toxicity)
- Oximes
(chemistry, therapeutic use)
- Rats
- Rats, Wistar
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