Abstract | OBJECTIVE: CASE REPORT: We report the case of a patient affected by XALD who developed Graves' hyperthyroidism (GH) and Graves' orbitopathy (GO) after BMT and who we could follow-up for 6.5 years afterwards. EVIDENCE SYNTHESIS: A boy affected by XALD was treated at the age of 6 years, with a whole BMT from his sister. One year after BMT, the transplanted patient presented TSH at the lower normal value and 3 years later he developed thyrotoxicosis. After a further 2 years, the patient developed GO, which showed clinical evidence of reactivation 5 years after its onset as a consequence of an attempt to treat thyrotoxicosis by means of I(131) (300 MBq). Seven years after BMT, the donor showed alterations of thyroid autoimmunity and 1 year thereafter she developed GH. She never presented GO during a subsequent 5 year follow-up. CONCLUSIONS: This case illustrates that autoimmunity originating from a pre-symptomatic donor can be transferred into the host during allogeneic stem cell transplantation. In cases where autoimmune phenomena are recognized in the donor prior to donation, alternative donors or T-cell manipulation of the graft might be considered.
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Authors | Y Vardizer, A Lupetti, S Vandelanotte, A C Lankester, W M Wiersinga, L Baldeschi |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 161
Issue 2
Pg. 369-73
(Aug 2009)
ISSN: 1479-683X [Electronic] England |
PMID | 19451211
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adrenoleukodystrophy
(immunology, surgery)
- Bone Marrow Transplantation
(adverse effects, immunology)
- Child
- Female
- Graves Disease
(etiology, immunology)
- Humans
- Male
- Thyrotropin
(blood)
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