Recurrence of Wegener's granulomatosis with de novo intraoral presentation treated successfully with rituximab.

Abstract

We describe a unique case of a recurrence of Wegener's granulomatosis (WG) that presented with oral pain involving a left maxillary molar, which thereafter led to an extraction. Oral lesions with a classical appearance of strawberry gingivitis developed following the extraction. The primary disease did not have any oral manifestations. Both the primary disease and recurrence responded to rituximab, a monoclonal B-cell depleting antibody. Rituximab is emerging as a drug with significant potential to improve treatment of primary and, as described in this case, recurrent WG.

• Authors: Konrad S Staines, Bernard Higgins
• Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics (Oral Surg Oral Med Oral Pathol Oral Radiol Endod) Vol. 108 Issue 1 Pg. 76-80 (Jul 2009) ISSN: 1528-395X [Electronic] United States
• PMID: 19451001 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Antibodies, Monoclonal
• Antibodies, Monoclonal, Murine-Derived
• Antigens, CD20
• Glucocorticoids
• Immunologic Factors
• Rituximab
• Prednisolone

Topics

• Adult
• Anti-Inflammatory Agents (therapeutic use)
• Antibodies, Monoclonal (therapeutic use)
• Antibodies, Monoclonal, Murine-Derived
• Antigens, CD20 (therapeutic use)
• Female
• Follow-Up Studies
• Gingivitis (diagnosis, drug therapy)
• Glucocorticoids (therapeutic use)
• Granulomatosis with Polyangiitis (diagnosis, drug therapy)
• Humans
• Immunologic Factors (therapeutic use)
• Prednisolone (therapeutic use)
• Recurrence
• Rituximab
• Tooth Extraction
• Toothache (therapy)