Pixantrone: a promising drug in the treatment of non-Hodgkin lymphomas.

Abstract

Pixantrone (BBR2778) is a novel anthracycline derivative, manufactured by Cell Therapeutics Incorporated, WA, USA. In both preclinical and clinical studies pixantrone exhibited a significantly lower cardiac toxicity and better activity than that observed with alternative anthracyclines, as it is devoid of the putative cardiac toxicity generating 5,8-dihydroxy groups. With single-agent pixantrone, neutropenia was the dose-limiting toxicity. In relapsed aggressive non-Hodgkin lymphomas, weekly single-agent pixantrone 85 mg/m(2) for 3 weeks every 4 weeks was associated with a 27% overall response rate and a 15% complete response rate. When used in combination with chemotherapy regimens overall response rates of 58-74% and complete response rates of 37-57% were achieved.

• Authors: Loaie M El-Helw, Barry W Hancock
• Journal: Future oncology (London, England) (Future Oncol) Vol. 5 Issue 4 Pg. 445-53 (May 2009) ISSN: 1744-8301 [Electronic] England
• PMID: 19450173 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Isoquinolines
• pixantrone

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Clinical Trials as Topic
• Humans
• Isoquinolines (pharmacology)
• Lymphoma, Non-Hodgkin (drug therapy)