Severe hemophagocytic syndrome developing after treatment initiation for disseminated Mycobacterium tuberculosis: case report and literature review.

Abstract

We describe a case of a young male with disseminated tuberculosis and severe secondary hemophagocytic syndrome. He presented with symptoms of tuberculosis and Mycobacterium tuberculosis was diagnosed. Later, while on anti-tuberculous treatment, he developed pancytopenia and bone marrow aspirate showed large macrophages with increased phagocytosis of mature and immature blood elements typical of hemophagocytic syndrome.

• Authors: Maher M Balkis, Lama Bazzi, Ali Taher, Ziad Salem, Imad Uthman, Nadim Kanj, Fouad I Boulos, Souha S Kanj
• Journal: Scandinavian journal of infectious diseases (Scand J Infect Dis) Vol. 41 Issue 6-7 Pg. 535-7 ( 2009) ISSN: 1651-1980 [Electronic] England
• PMID: 19449255 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antitubercular Agents

Topics

• Adult
• Antitubercular Agents (adverse effects, therapeutic use)
• Humans
• Lymphohistiocytosis, Hemophagocytic (chemically induced, etiology, microbiology)
• Male
• Mycobacterium tuberculosis
• Treatment Outcome
• Tuberculosis (complications, drug therapy)