Abstract | CONTEXT: Reduced bone mineral density (BMD) and increased risk of fractures are present in many women with Turner syndrome (TS). OBJECTIVE: Examine longitudinal changes in BMD in TS and relate changes to biochemical parameters. DESIGN: Prospective, pragmatic, and observational study. Examinations at baseline and follow-up (5.9+/-0.7 years). SETTING: Tertiary hospital. PARTICIPANTS: Fifty-four women with TS (43.0+/-9.95 years). Interventions Hormone replacement therapy (HRT) and calcium and vitamin D supplementation. Main outcome measures BMD (g/cm(2)) measured at lumbar spine, hip, and the non-dominant forearm. Bone formation and resorption markers, sex hormones, IGF1, and maximal oxygen uptake. RESULTS: At follow-up, forearm BMD, radius ultradistal BMD, and hip BMD remained unchanged, radius 1/3 BMD declined (0.601+/-0.059 vs 0.592+/-0.059, P=0.03), while spine BMD increased (0.972+/-0.139 vs 1.010+/-0.144, P<0.0005). Bone formation markers did not change over time in TS. Bone resorption markers decreased over time in TS. Testosterone, IGF1, and maximal oxygen uptake was significantly reduced in TS. CONCLUSION: Longitudinal changes in BMD in TS were slight. BMD can be maintained at most sites in well-informed women with TS, being encouraged to maintain a healthy lifestyle, including HRT and intake of calcium and vitamin D.
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Authors | Line Cleemann, Britta E Hjerrild, Anna L Lauridsen, Lene Heickendorff, Jens S Christiansen, Leif Mosekilde, Claus H Gravholt |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 161
Issue 2
Pg. 251-7
(Aug 2009)
ISSN: 1479-683X [Electronic] England |
PMID | 19447901
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Estrogens
- Vitamin D
- Calcium
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Topics |
- Absorptiometry, Photon
- Adult
- Aged
- Bone Density
(drug effects)
- Bone and Bones
(drug effects, metabolism)
- Calcium
(administration & dosage)
- Estrogen Replacement Therapy
(methods)
- Estrogens
(administration & dosage)
- Exercise
- Female
- Heart Rate
(physiology)
- Humans
- Longitudinal Studies
- Middle Aged
- Prospective Studies
- Turner Syndrome
(drug therapy, metabolism)
- Vitamin D
(administration & dosage)
- Young Adult
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