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Discovery of diphenylmethane analogs as anti-bovine diarrhea viral agents.

Abstract
Based on antiviral screening of our diphenylmethane derivatives prepared as steroid substitutes, we identified a 1,1-diphenylcyclobutane analog (9) and two diethyldiphenylsilane analogs (12 and 13) as superior lead compounds with potent anti-bovine viral diarrhea virus (BVDV) activity, having 50% effective concentration (EC(50): based on reduction of BVDV replication-induced cell destruction) and 50% cytotoxic concentration (CC(50): based on reduction of viable cell number) values of 6.2-8.4 microM and >100 microM, respectively, in Madin-Darby bovine kidney (MDBK) cells infected with BVDV.
AuthorsShinnosuke Hosoda, Hiroshi Aoyama, Yukinori Goto, Mohammed T A Salim, Mika Okamoto, Mariko Hashimoto, Masanori Baba, Yuichi Hashimoto
JournalBioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 19 Issue 12 Pg. 3157-61 (Jun 15 2009) ISSN: 1464-3405 [Electronic] England
PMID19447037 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antiviral Agents
  • Benzhydryl Compounds
  • Steroids
  • diphenylmethane
Topics
  • Animals
  • Antiviral Agents (chemical synthesis, chemistry, pharmacology)
  • Benzhydryl Compounds (chemical synthesis, chemistry, pharmacology)
  • Bovine Virus Diarrhea-Mucosal Disease (drug therapy)
  • Cattle
  • Cell Line
  • Cell Survival (drug effects)
  • Diarrhea Viruses, Bovine Viral (drug effects)
  • Drug Evaluation, Preclinical
  • Steroids (chemistry)
  • Structure-Activity Relationship
  • Virus Replication (drug effects)

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