Abstract |
Based on antiviral screening of our diphenylmethane derivatives prepared as steroid substitutes, we identified a 1,1-diphenylcyclobutane analog (9) and two diethyldiphenylsilane analogs (12 and 13) as superior lead compounds with potent anti-bovine viral diarrhea virus (BVDV) activity, having 50% effective concentration (EC(50): based on reduction of BVDV replication-induced cell destruction) and 50% cytotoxic concentration (CC(50): based on reduction of viable cell number) values of 6.2-8.4 microM and >100 microM, respectively, in Madin-Darby bovine kidney (MDBK) cells infected with BVDV.
|
Authors | Shinnosuke Hosoda, Hiroshi Aoyama, Yukinori Goto, Mohammed T A Salim, Mika Okamoto, Mariko Hashimoto, Masanori Baba, Yuichi Hashimoto |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 19
Issue 12
Pg. 3157-61
(Jun 15 2009)
ISSN: 1464-3405 [Electronic] England |
PMID | 19447037
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antiviral Agents
- Benzhydryl Compounds
- Steroids
- diphenylmethane
|
Topics |
- Animals
- Antiviral Agents
(chemical synthesis, chemistry, pharmacology)
- Benzhydryl Compounds
(chemical synthesis, chemistry, pharmacology)
- Bovine Virus Diarrhea-Mucosal Disease
(drug therapy)
- Cattle
- Cell Line
- Cell Survival
(drug effects)
- Diarrhea Viruses, Bovine Viral
(drug effects)
- Drug Evaluation, Preclinical
- Steroids
(chemistry)
- Structure-Activity Relationship
- Virus Replication
(drug effects)
|