CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus.

Abstract

Studying the mechanisms of host survival resulting from viral encephalitis is critical to the development of vaccines. Here we have shown in several independent studies that high dose treatment with neutralizing antibody prior to intranasal infection with Venezuelan equine encephalitis virus had an antiviral effect in the visceral organs and prolonged survival time of infected mice, even in the absence of alphabeta T cells. Nevertheless, antibody treatment did not prevent the development of lethal encephalitis. On the contrary, the adoptive transfer of primed CD4(+) T cells was necessary to prevent lethal encephalitis in mice lacking alphabeta T cell receptor.

• Authors: Nadezhda E Yun, Bi-Hung Peng, Andrea S Bertke, Viktoriya Borisevich, Jennifer K Smith, Jeanon N Smith, Allison L Poussard, Milagros Salazar, Barbara M Judy, Michele A Zacks, D Mark Estes, Slobodan Paessler
• Journal: Vaccine (Vaccine) Vol. 27 Issue 30 Pg. 4064-73 (Jun 19 2009) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 19446933 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Viral
• Receptors, Antigen, T-Cell

Topics

• Adoptive Transfer
• Animals
• Antibodies, Viral (administration & dosage, immunology)
• CD4-Positive T-Lymphocytes (immunology)
• Encephalitis Virus, Venezuelan Equine (immunology)
• Encephalomyelitis, Venezuelan Equine (immunology, prevention & control)
• Female
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Knockout
• Neutralization Tests
• Receptors, Antigen, T-Cell (deficiency)
• Survival Analysis