Metastatic acinar cell carcinoma of the pancreas responding to gemcitabine, 5-fluorouracil and leucovorin therapy: a case report.

Abstract

Acinar cell carcinoma of the pancreas is rare tumour with a generally poor prognosis. There are very few reports of tumour regression following chemotherapy. In this case report, a patient with metastatic acinar cell carcinoma in the liver developed progressive disease after cisplatin/etoposide and then had progressive disease after weekly paclitaxel chemotherapy. However, his tumour then responded to gemcitibine/5-flourouracil/leucovorin chemotherapy. Herein, previously described chemotherapy regimens used for this rare tumour are reviewed. This case represents the first reported metastatic acinar cell carcinoma responding to this regimen.

• Authors: S M Sorscher
• Journal: European journal of cancer care (Eur J Cancer Care (Engl)) Vol. 18 Issue 3 Pg. 318-9 (May 2009) ISSN: 1365-2354 [Electronic] England
• PMID: 19445023 (Publication Type: Case Reports, Journal Article)

Chemical References

• Deoxycytidine
• Vitamin B Complex
• Leucovorin
• Fluorouracil
• Gemcitabine

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Carcinoma, Acinar Cell (drug therapy, secondary)
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Drug Resistance, Neoplasm
• Fluorouracil (administration & dosage)
• Humans
• Leucovorin (administration & dosage)
• Liver Neoplasms (drug therapy, secondary)
• Male
• Middle Aged
• Pancreatic Neoplasms
• Treatment Outcome
• Vitamin B Complex (administration & dosage)
• Gemcitabine