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Low susceptibility to inert gases and pressure symptoms in TREK-1-deficient mice.

Abstract
Nervous disorders may occur after an organism is saturated with inert gases, which may alter the lipid bilayer structure, according to their liposolubility coefficient. Increase in the nitrogen partial pressure induces a neurological syndrome called 'nitrogen narcosis'. By contrast, high pressures of helium induce epilepsy, an high-pressure nervous syndrome symptom. On the basis of an analogy with anaesthetic mechanisms, we used TREK-1 knockout mice, earlier described to volatile the anaesthetics resistance. These mice had a higher threshold of resistance to the narcotic effects of nitrogen and to the death after recurrent epileptic seizure induced by high pressure. TREK-1 channels seem to play a key role in modulating the anaesthetic potential of inert gases and in neuroprotection.
AuthorsNicolas Vallée, Jean-Claude Rostain, Jean-Jacques Risso
JournalNeuroreport (Neuroreport) Vol. 20 Issue 3 Pg. 343-7 (Feb 18 2009) ISSN: 1473-558X [Electronic] England
PMID19444956 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anesthetics, Inhalation
  • Membrane Lipids
  • Potassium Channels, Tandem Pore Domain
  • potassium channel protein TREK-1
  • Helium
  • Nitrogen
Topics
  • Anesthetics, Inhalation (toxicity)
  • Animals
  • Atmospheric Pressure
  • Brain (drug effects, metabolism, physiopathology)
  • Drug Resistance (genetics)
  • Epilepsy (chemically induced, genetics, physiopathology)
  • Helium (toxicity)
  • High Pressure Neurological Syndrome (genetics, metabolism, physiopathology)
  • Hyperbaric Oxygenation (adverse effects)
  • Immunity, Innate (genetics)
  • Inert Gas Narcosis (genetics, metabolism, physiopathology)
  • Membrane Lipids (metabolism)
  • Mice
  • Mice, Knockout
  • Neurons (drug effects, metabolism)
  • Nitrogen (toxicity)
  • Potassium Channels, Tandem Pore Domain (genetics)
  • Pressure (adverse effects)

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