Since quite some time relapsing herpes simplex virus
infections of the skin are clinically successfully treated with a heat-
inactivated vaccine Lupidon G and Lupidon H respectively, although nothing is known as yet regarding the working principle of this
therapy, which bases on immunological reflections. It was, therefore, examined by the
complement fixing and
neutralizing antibodies against herpes simplex virus of 11 patients and 3 control individuals if repeated
injections of this
vaccine cause alterations of the specific antibody titer. Skin tests were made in addition with 9 patient prior to and 8 weeks after
therapy at the earliest. During the entire eamination period of at least 8 weeks up to 9 months the
complement fixing as well as the
neutralizing antibody titer remained practically constant and in none of the examined cases the skin tests caused any reaction. Since it is, however, known, e.g. from the examinations by Lehner, that seropositive individuals reacta to herpes virus with symptoms of an
allergy of the delayed type, is must particularly be considered in furture examinations on the working mechanism of Lupidon that the Lupidon solutions for intracutaneous testing must be of considerably higher concentration. The questition of the site of action of Lupidon at the
interferon mechanism remains pending in addition.