Abstract | BACKGROUND: METHODS AND RESULTS: The Prevention of Cerebrovascular and Cardiovascular Events of Ischemic Origin with Terutroban in Patients with a History of Ischemic Stroke or Transient Ischemic Attack (PERFORM) Study is an international, multicenter, randomized, double-blind, parallel-group study in patients aged > or =55 years who have suffered ischemic strokes (<3 months) or transient ischemic attacks (<8 days), and who are stable at inclusion with no intracranial hemorrhage or nonischemic neurological diseases. Patients are randomly allocated to terutroban (30 mg/day) or aspirin (100 mg/day). The primary efficacy end point is a composite of ischemic stroke (fatal or nonfatal), myocardial infarction (fatal or nonfatal), or other vascular death (excluding hemorrhagic death of any origin). Safety is evaluated by assessing hemorrhagic events. The first patient was randomized in February 2006 and more than 19,000 patients will be included. CONCLUSIONS:
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Authors | Michael G Hennerici, PERFORM Study Investigators |
Journal | Cerebrovascular diseases (Basel, Switzerland)
(Cerebrovasc Dis)
Vol. 27 Suppl 3
Pg. 28-32
( 2009)
ISSN: 1421-9786 [Electronic] Switzerland |
PMID | 19439938
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright 2009 S. Karger AG, Basel. |
Chemical References |
- Naphthalenes
- Propionates
- terutroban
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Topics |
- Brain Ischemia
(prevention & control)
- Humans
- Ischemic Attack, Transient
(prevention & control)
- Multicenter Studies as Topic
(methods)
- Naphthalenes
(therapeutic use)
- Propionates
(therapeutic use)
- Randomized Controlled Trials as Topic
(methods)
- Stroke
(prevention & control)
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