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Prosthetic valve endocarditis caused by metallo-beta-lactamase-producing Pseudomonas aeruginosa.

Abstract
Prosthetic valve endocarditis (PVE) caused by Pseudomonas aeruginosa is a rare but life-threatening complication. Early surgical intervention, as well as appropriate antimicrobial therapy, is usually necessary. Recently, problems have arisen regarding infection with P. aeruginosa, which produces metallo-beta-lactamase (MBL) and is resistant to virtually all beta-lactams. This organism has rapidly spread through many countries. Here, we report the first case of successful redo aortic valve replacement using a Prima Plus stentless valve (Edwards Lifesciences, Irvine, CA, USA) followed by a 6-week course of ciprofloxacin and gentamicin for early PVE caused by MBL-producing P. aeruginosa.
AuthorsYasuyuki Kato, Hirokazu Ohashi, Yasushi Tsutsumi, Tadahiro Murakami, Yosuke Takahashi
JournalJournal of cardiac surgery (J Card Surg) 2009 May-Jun Vol. 24 Issue 3 Pg. 347-9 ISSN: 1540-8191 [Electronic] United States
PMID19438796 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Gentamicins
  • Ciprofloxacin
  • metallo-beta-lactamase (VIM-13), Pseudomonas aeruginosa
  • beta-Lactamases
Topics
  • Aged
  • Anti-Bacterial Agents (therapeutic use)
  • Aortic Valve Stenosis (surgery)
  • Ciprofloxacin (therapeutic use)
  • Drug Therapy, Combination
  • Echocardiography
  • Endocarditis, Bacterial (diagnosis, drug therapy, microbiology)
  • Follow-Up Studies
  • Gentamicins (therapeutic use)
  • Heart Valve Prosthesis (adverse effects, microbiology)
  • Humans
  • Male
  • Prosthesis-Related Infections (diagnosis, drug therapy, microbiology)
  • Pseudomonas Infections (diagnosis, drug therapy, microbiology)
  • Pseudomonas aeruginosa (enzymology, isolation & purification)
  • beta-Lactamases (biosynthesis)

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