Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: KEY RESULTS: Preventive or therapeutic treatments with alpha-humulene, but not with trans-caryophyllene, significantly reduced the eosinophil recruitment to the BALF. In addition, alpha-humulene recovery INF-gamma and reduced the IL-5, CCL11 and LTB(4) levels in BALF, as well as the IL-5 production in mediastinal lymph nodes (in vitro assay). Furthermore, alpha-humulene decreased the NF-kB and the AP-1 activation, the expression of P-selectin and the increased mucus secretion in the lung. CONCLUSIONS AND IMPLICATIONS:
alpha-Humulene, given either orally or by aerosol, exhibited marked anti-inflammatory properties in a murine model of airways allergic inflammation, an effect that seemed to be mediated via reduction of inflammatory mediators, adhesion molecule expression and transcription factors activation.
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Authors | Alexandre P Rogerio, Edinéia L Andrade, Daniela F P Leite, Cláudia P Figueiredo, João B Calixto |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 158
Issue 4
Pg. 1074-87
(Oct 2009)
ISSN: 1476-5381 [Electronic] England |
PMID | 19438512
(Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aerosols
- Anti-Inflammatory Agents
- Ccl11 protein, mouse
- Chemokine CCL11
- Interleukin-5
- Monocyclic Sesquiterpenes
- NF-kappa B
- Sesquiterpenes
- Transcription Factor AP-1
- Leukotriene B4
- humulene
- Interferon-gamma
- Ovalbumin
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Topics |
- Administration, Oral
- Aerosols
- Animals
- Anti-Inflammatory Agents
(administration & dosage, pharmacology, therapeutic use)
- Bronchoalveolar Lavage Fluid
(chemistry, immunology)
- Chemokine CCL11
(analysis)
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Eosinophils
(drug effects)
- Female
- Immunohistochemistry
- Interferon-gamma
(analysis)
- Interleukin-5
(analysis)
- Leukotriene B4
(analysis)
- Lung
(drug effects, metabolism, pathology)
- Mice
- Mice, Inbred BALB C
- Monocyclic Sesquiterpenes
- Monocytes
(drug effects)
- NF-kappa B
(analysis, metabolism)
- Neutrophils
(drug effects)
- Ovalbumin
(administration & dosage, immunology)
- Respiratory Hypersensitivity
(drug therapy, pathology)
- Sesquiterpenes
(administration & dosage, pharmacology, therapeutic use)
- Transcription Factor AP-1
(analysis, metabolism)
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