Using 'number needed to treat' to help conceptualize the magnitude of benefit and risk of tumour necrosis factor-alpha inhibitors for patients with severe psoriasis.

Abstract

BACKGROUND:

Risks and benefits of tumour necrosis factor (TNF) alpha inhibitors are often presented using statistical descriptions that are difficult to translate directly for patients into a clinically meaningful context.

OBJECTIVES:

To illustrate the risks and benefits of TNFalpha inhibitors in relation to risks that patients understand.

METHODS:

We performed a number needed to treat analysis for patients with psoriasis on TNFalpha inhibitors via a Medline and Embase search. We determined the number needed to benefit and the number needed to harm with TNFalpha inhibitor treatment. We compared the risk of serious adverse events from treatment with a TNFalpha inhibitor to the risk of death from driving a car. The risk analyses were limited to the risks of tuberculosis, lymphoma and demyelinating disease.

RESULTS:

The numbers needed to benefit were 2.1 for etanercept, 1.4 for infliximab, and 1.6 for adalimumab. Depending on the adverse event, the numbers needed to harm ranged from 380 to 360,000 treated patients per year. Screening prior to the initiation of TNFalpha inhibitor therapy reduces risk of tuberculosis. Patients are about as likely to die in a car accident as to have a serious adverse event from treatment with a TNFalpha inhibitor.

CONCLUSIONS:

All three of the TNFalpha antagonists have remarkable efficacy in patients with severe psoriasis. The risks of serious adverse events are relatively rare and comparable to the risks patients take on a regular basis such as driving a car. For many patients with severe psoriasis, the benefits of TNFalpha inhibitors may greatly outweigh the risks.

• Authors: J W Dharamsi, M Bhosle, R Balkrishnan, B A Yentzer, S R Feldman
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 161 Issue 3 Pg. 605-16 (Sep 2009) ISSN: 1365-2133 [Electronic] England
• PMID: 19438475 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antibodies, Monoclonal
• Immunosuppressive Agents
• Tumor Necrosis Factor-alpha

Topics

• Antibodies, Monoclonal (therapeutic use)
• Data Interpretation, Statistical
• Humans
• Immunosuppressive Agents (adverse effects, therapeutic use)
• Psoriasis (drug therapy)
• Risk Assessment (methods)
• Sample Size
• Tumor Necrosis Factor-alpha (antagonists & inhibitors)