Abstract | BACKGROUND AND AIMS: SUBJECTS AND METHODS: A meal was given to 30 obese (age 34 +/- 1 yr, body mass index 47 +/- 1 kg/m(2)) and 10 nonobese women (age 39 +/- 4 yr, body mass index 23 +/- 1 kg/m(2)). Samples for glucose and insulin were taken for 360 min from veins draining the abdominal subcutaneous AD and forearm muscles and from the radial artery. Blood flow (BF) was measured in AD ((133)Xe) and M (plethysmography). RESULTS: The area under the curve divided by time (AUC(0-360 min)/360 min) in obese vs. nonobese was as follows: 1) arterial glucose was similar 6.04 +/- 0.2 vs. 5.67 +/- 0.1 mm), but insulin was increased (65.5 +/- 6.6 vs. 28.7 +/- 1.7 mU/liter, P = 0.0004); 2) BF was decreased (3 +/- 0.2 vs. 4.4 +/- 0.3 ml/min per 100 ml tissue in M, P = 0.002 and 1.8 +/- 0.1 vs. 3.7 +/- 0.3 ml/min per 100 ml tissue in AD, P < 0.0001); 3) glucose uptake was decreased (0.9 +/- 0.1 vs. 2.3 +/- 0.4 micromol/min per 100 ml tissue in M, P = 0.002 and 0.45 +/- 0.1 vs. 1.1 +/- 0.17 micromol/min per 100 ml tissue in AD, P = 0.01); 4) fractional glucose extraction was decreased in M (5 +/- 1 vs. 9 +/- 1%, P = 0.03), but was similar in AD (3 +/- 1 vs. 3.6 +/- 1.4%); 5) glucose uptake (per total fat mass) was increased (0.275 +/- 0.04 vs. 0.12 +/- 0.02 mmol/min, P = 0.027). CONCLUSION:
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Authors | Panayota Mitrou, Eleni Boutati, Vaia Lambadiari, Eirini Maratou, Alexandros Papakonstantinou, Vasiliki Komesidou, Labros Sidossis, Nikolaos Tountas, Nikolaos Katsilambros, Theofanis Economopoulos, Sotirios A Raptis, George Dimitriadis |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 94
Issue 8
Pg. 2958-61
(Aug 2009)
ISSN: 1945-7197 [Electronic] United States |
PMID | 19435828
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Insulin
- Glucose
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Topics |
- Adipose Tissue
(blood supply, metabolism)
- Adult
- Area Under Curve
- Blood Glucose
(analysis)
- Female
- Glucose
(metabolism)
- Humans
- Insulin
(blood)
- Muscle, Skeletal
(metabolism)
- Obesity, Morbid
(metabolism)
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