Abstract | BACKGROUND: METHODS: Forty-two cases of OK, 26 cases of dentigerous cyst (DC), and 15 cases of residual cyst (RC) were retrospectively examined by immunohistochemistry for VEGF, Ki67/Mib-1 and anti-caspase-3. For VEGF and caspase-3, the intensity of immunostaining was qualitatively assessed, while for the evaluation of Ki67 the average number of positively stained nuclei in 10 high-power microscopic fields (x 400) was calculated. RESULTS: The VEGF expression was stronger in OK when compared with DC (P < 0.007). The rate of nuclear Ki67 expression in OK was significantly higher than that in DC (P < 0.001) and RC (P < 0.001). Cytoplasmic caspase-3 expression was statistically more intense in RC than in OK (P = 0.001) or DC (P < 0.001). A statistically significant correlation was seen in OK for Ki67 (P < 0.001) and VEGF (P = 0.023), but not for caspase-3. Multiple regression analysis revealed a linear relationship between VEGF and Ki67. CONCLUSIONS: The VEGF was expressed in the epithelium of OK, DC, and RC with a variable intensity, and in OK VEGF expression was related to Ki67. It is suggested that VEGF expression by the odontogenic epithelium is not induced solely by inflammation.
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Authors | G K Mitrou, K I Tosios, A Kyroudi, A Sklavounou |
Journal | Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
(J Oral Pathol Med)
Vol. 38
Issue 5
Pg. 470-5
(May 2009)
ISSN: 1600-0714 [Electronic] Denmark |
PMID | 19434817
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Ki-67 Antigen
- Vascular Endothelial Growth Factor A
- Caspase 3
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Topics |
- Adult
- Caspase 3
(metabolism)
- Dentigerous Cyst
(metabolism, pathology)
- Female
- Humans
- Immunohistochemistry
- Ki-67 Antigen
(metabolism)
- Male
- Middle Aged
- Odontogenic Cysts
(metabolism, pathology)
- Retrospective Studies
- Tissue Distribution
- Vascular Endothelial Growth Factor A
(metabolism)
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