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Antiinflammatory evaluation of a Pluchea indica root extract.

Abstract
A methanolic fraction of a chloroform extract of defatted Pluchea indica roots was investigated for its antiinflammatory potential against several models of inflammation. The extract showed significant inhibitory activity against carrageenin-, histamine-, serotonin-, hyaluronidase- and sodium urate-induced pedal inflammation. The extract inhibited protein exudation and leucocyte migration. The extract also inhibited carrageenin- and cotton pellet-induced granuloma formation as well as turpentine-induced joint oedema and adjuvant-induced polyarthritis. The present observations establish the efficacy of the extract in the exudative, proliferative and chronic stages of inflammation.
AuthorsT Sen, A K Nag Chaudhuri
JournalJournal of ethnopharmacology (J Ethnopharmacol) 1991 May-Jun Vol. 33 Issue 1-2 Pg. 135-41 ISSN: 0378-8741 [Print] Ireland
PMID1943162 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Plant Extracts
  • Uric Acid
  • Serotonin
  • Histamine
  • Carrageenan
  • Hyaluronoglucosaminidase
  • Phenylbutazone
  • Turpentine
Topics
  • Adrenalectomy
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
  • Arthritis, Experimental (prevention & control)
  • Carrageenan
  • Cell Migration Inhibition
  • Edema (chemically induced, drug therapy)
  • Exudates and Transudates (physiology)
  • Gossypium
  • Granuloma (chemically induced, prevention & control)
  • Histamine
  • Hyaluronoglucosaminidase
  • India
  • Mice
  • Phenylbutazone (pharmacology)
  • Plant Extracts (pharmacology)
  • Plants, Medicinal (chemistry)
  • Pleurisy (chemically induced, drug therapy)
  • Rats
  • Serotonin
  • Turpentine
  • Uric Acid

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