Abstract | BACKGROUND AND OBJECTIVES: The causal treatment of chronic pruritus is not always possible or effective necessitating symptomatic antipruritic therapy. Antihistamines are the only drugs approved for the treatment of chronic pruritus, but they are rarely effective at standard doses. The aim of this investigation was to describe the efficacy and safety of high-dosage antihistamine treatment in patients with chronic pruritus of different origin. PATIENTS: RESULTS: CONCLUSIONS: The results of this case series suggest a high antipruritic effect in chronic pruritus by administration of high-dosage, non- sedating antihistamines. These results have to be confirmed in controlled trials. The combination was not more effective than the high dosage monotherapy. The latter one might be preferable due to unknown interactions and addition of side-effects in the combination therapy.
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Authors | S Schulz, M Metz, D Siepmann, T A Luger, M Maurer, S Ständer |
Journal | Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
(Hautarzt)
Vol. 60
Issue 7
Pg. 564-8
(Jul 2009)
ISSN: 1432-1173 [Electronic] Germany |
Vernacular Title | Antipruritische Wirksamkeit einer hoch dosierten Antihistaminikatherapie. Ergebnisse einer retrospektiv analysierten Fallserie. |
PMID | 19430742
(Publication Type: Controlled Clinical Trial, English Abstract, Journal Article)
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Chemical References |
- Antipruritics
- Histamine Antagonists
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antipruritics
(administration & dosage)
- Case-Control Studies
- Chronic Disease
- Dose-Response Relationship, Drug
- Histamine Antagonists
(administration & dosage)
- Humans
- Middle Aged
- Pruritus
(diagnosis, drug therapy)
- Retrospective Studies
- Treatment Outcome
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